Design and synthesis of novel quinazolin‐4(1H)‐one derivatives as potent and selective inhibitors targeting AKR1B1
Sign Up to like & getrecommendations! Published in 2023 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200577
Abstract: Inhibition of aldose reductase (AKR1B1) is a promising option for the treatment of diabetic complications. However, most of the developed small molecule inhibitors lack selectivity or suffer from low bioactivity. To address this limitation, a… read more here.
Keywords: design synthesis; derivatives potent; quinazolin one; selective inhibitors ... See more keywords
Novel spiro[indene‐1,2′‐quinazolin]‐4′(3′H)‐one derivatives as potent anticonvulsant agents: One‐pot synthesis, in vivo biological evaluation, and molecular docking studies
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23234
Abstract: A new series of spiro[indene‐1,2′‐quinazolin]‐4′(3′H)‐one derivatives 4a–m were synthesized via a one‐pot method and evaluated for anticonvulsant activities using pentylenetetrazole (PTZ) and maximal electroshock (MES)‐induced seizures. Obtained results demonstrated that these compounds have not anticonvulsant… read more here.
Keywords: spiro indene; compound; quinazolin one; indene quinazolin ... See more keywords
Quinazolin-4(3H)-one based agents bearing thiadiazole-urea: Synthesis and evaluation of anti-proliferative and antiangiogenic activity.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104553
Abstract: A series of quinazolin-4(3H)-one based agents containing thiadiazole-urea were designed, synthesized, and biologically evaluated. The proliferation rate of PC3 cells was moderately reduced by compound 9f (IC50 = 17.7 μM)which was comparable with sorafenib (IC50 = 17.3 μM). There… read more here.
Keywords: agents bearing; based agents; one based; quinazolin one ... See more keywords
11H-Pyrido[2,1-b]quinazolin-11-one - A reversible Turn-on/off Fluorescent Probe for Solution and Gas-phase Detection of Acids or Basic Amines
Sign Up to like & getrecommendations! Published in 2021 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2021.109536
Abstract: Abstract The present study details a metal- and solvent-free synthesis of 11H-pyrido[2,1-b]quinazolin-11-one (1) and its photophysical properties as an acid or base-sensitive sensor. The absorption spectra in organic solvents revealed a small blue shift on… read more here.
Keywords: basic amines; quinazolin one; pyrido quinazolin; acids basic ... See more keywords
Synthesis and evaluation of new quinazolin-4(3H)-one derivatives as potent antibacterial agents against multidrug resistant Staphylococcus aureus and Mycobacterium tuberculosis.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.04.067
Abstract: Staphylococcus aureus and Mycobacterium tuberculosis are major causative agents responsible for serious nosocomial and community-acquired infections impacting healthcare systems globally. Over several decades, these pathogens have developed resistance to multiple antibiotics significantly affecting morbidity and… read more here.
Keywords: antibacterial agents; one derivatives; quinazolin one; staphylococcus aureus ... See more keywords
Quinazolin-4(3H)-one based potential multiple tyrosine kinase inhibitors with excellent cytotoxicity
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2021.1972992
Abstract: A series of quinazolin-4(3H)-one derivatives were synthesised and evaluated for their cytotoxicity against human Caucasian breast adenocarcinoma (MCF-7) and human ovarian carcinoma (A2780) cell lines. Cytotoxicity of the most tested compounds was 2- to 30-fold… read more here.
Keywords: multiple tyrosine; one derivatives; kinase; quinazolin one ... See more keywords
Synthesis and corrosion inhibition effects of quinazolin-(3H)-4-one derivatives containing long-chain pyridinium salts on carbon steel in 1.5 M HCl
Sign Up to like & getrecommendations! Published in 2017 at "Protection of Metals and Physical Chemistry of Surfaces"
DOI: 10.1134/s2070205117050161
Abstract: Quinazolin-4(3H)-one derivatives containing long-chain pyridinium salts were synthesized by a quaternization reaction of pyridine. The confirmation of the synthesized compounds structure was performed by FT-IR, 1H NMR and 13C NMR spectroscopy. Corrosion inhibition tests were… read more here.
Keywords: chain; corrosion inhibition; inhibition; corrosion ... See more keywords
Synthesis and Anti-Proliferative Evaluations of New Heterocyclic Derivatives using 5,6,8,9-tetrahydropyrazolo[5,1-b]quinazolin-7(3H)-one Derivatives Derived from Cyclohexa-1,4-dione.
Sign Up to like & getrecommendations! Published in 2020 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520620666200523162549
Abstract: BACKGROUND Recentlty pyrazoloquinazoline derivatives acquired a special attention due to their wide range of pharmacological activities especially the therapeutic activities. Through the market it was found that many pharmacological drugs containing the quinazoline nucleus were… read more here.
Keywords: tetrahydropyrazolo quinazolin; one derivatives; derivatives using; quinazolin one ... See more keywords
Synthesis of New Phenolic Derivatives of Quinazolin-4(3H)-One as Potential Antioxidant Agents—In Vitro Evaluation and Quantum Studies
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DOI: 10.3390/molecules27082599
Abstract: Considering the important damage caused by the reactive oxygen (ROS) and nitrogen (RNS) species in the human organism, the need for new therapeutic agents, with superior efficacy to the known natural and synthetic antioxidants, is… read more here.
Keywords: phenolic derivatives; quantum; quinazolin one; derivatives quinazolin ... See more keywords
Antiproliferative Activity of a New Quinazolin-4(3H)-One Derivative via Targeting Aurora Kinase A in Non-Small Cell Lung Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15060698
Abstract: Non-small cell lung cancer (NSCLC) is the most common lung cancer subtype. Although chemotherapy and targeted therapy are used for the treatment of patients with NSCLC, the survival rate remains very low. Recent findings suggested… read more here.
Keywords: lung cancer; cell; quinazolin one; activity ... See more keywords