One-pot synthesis of benzo[4,5]imidazo[1,2-c]quinazolin-6(5H)-ones under catalyst-free conditions and their X-ray crystallographic studies
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.130037
Abstract: Abstract We have developed a perceptive and facile approach for the synthesis of new benzo[4,5]imidazo[1,2-c]quinazolin-6(5H)-one derivatives by one-pot two component condensation involving various o-phenylenediamines and substituted isatins in aqueous ethanol at 80 °C. In this methodology,… read more here.
Keywords: imidazo quinazolin; benzo imidazo; quinazolin ones;
Synthesis of novel glycosyl-1,2,3-1H-triazolyl methyl quinazolin-4(3H)-ones and their effect on GLUT4 translocation
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2016.11.074
Abstract: Cu(OTf)2 catalyzed synthesis of propargylated 2,3-dihydroquinazolin-4(1H)-ones has been accomplished from 2-amino-N-propargyl benzamides and aromatic aldehydes under MW irradiation. Next, a series of novel glycosyl triazolyl methyl quinazolin-4(3H)-ones have been synthesized by CuAAC reaction of propargylated… read more here.
Keywords: novel glycosyl; glut4 translocation; triazolyl methyl; quinazolin ones ... See more keywords
Palladium(II) N^O Chelating Complexes Catalyzed One-Pot Approach for Synthesis of Quinazolin-4(3H)-ones via Acceptorless Dehydrogenative Coupling of Benzyl Alcohols and 2-Aminobenzamide
Sign Up to like & getrecommendations! Published in 2021 at "Organometallics"
DOI: 10.1021/acs.organomet.0c00814
Abstract: A convenient protocol for the one-pot synthesis of quinazolin-4(3H)-ones using palladium(II) complexes via dehydrogenative coupling of readily available benzyl alcohols and 2-aminobenzamide has bee... read more here.
Keywords: synthesis quinazolin; quinazolin ones; one pot; benzyl alcohols ... See more keywords
Silver Nitrate-Catalyzed Isocyanide Insertion/Lactamization Sequence to Imidazolones and Quinazolin-4-ones: Development and Application in Natural Product Synthesis.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b02334
Abstract: Silver nitrate-catalyzed reaction of methyl α,α-disubstituted α-isocyanoacetates with primary amines afforded 3,5,5-trisubstituted imidazolones in good to excellent yields. A silver salt-catalyzed insertion of the isocyano group into the N-H bond of the amine followed by… read more here.
Keywords: lactamization; insertion; nitrate catalyzed; quinazolin ones ... See more keywords
Cu-Catalyzed Direct Diversification of 2-(2-Bromophenyl)quinazolin-4(3H)-ones through Orthogonal Reactivity Modulation.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03428
Abstract: A modular strategy to obtain three different products from a single substrate was developed. The present methodology unveils new step-economical and cost-efficient routes to access diverse fused quinazolinoquinazolinone derivatives which are not prevalent in literature.… read more here.
Keywords: bromophenyl quinazolin; ones orthogonal; diversification bromophenyl; quinazolin ones ... See more keywords
The Rh(iii)-catalysed C–H/N–H annulation of 2-thienyl- and 2-phenyl-quinazolin-4(3H)-ones with diphenylacetylene
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DOI: 10.1039/d1nj00935d
Abstract: 2-Thienyl/phenyl substituted quinazolin-4(3H)-ones were converted into 4,5-diphenyl-7H-thieno[2′,3′:3,4]pyrido[2,1-b]quinazolin-7-ones or amide alcoholysis product via Rh(iii)-catalyzed reaction of with diphenylacetylene. read more here.
Keywords: thienyl phenyl; iii catalysed; quinazolin ones;
Design, Synthesis and Anti-inflammatory Activity of Derivatives 10-R-3-Aryl-6,7-dihydro-2H-[1,2,4] triazino[2,3-c]quinazolin-2-ones of Spiro-fused Cyclic Frameworks.
Sign Up to like & getrecommendations! Published in 2017 at "Acta chimica Slovenica"
DOI: 10.17344/acsi.2017.3575
Abstract: Present work is devoted to the purposeful search of novel promising anti-inflammatory agents among the insufficiently known 3'-R-10'-R1-spiro[hetaryl-3(4),6'-[1,2,4]triazino[2,3-c]quinazolin]-2'(7'H)-ones. The virtual combinatorial library of previously unknown spiro-condensed derivatives of [1,2,4]triazino[2,3-c]quinazolines was formed and promising COX-2 inhibitors… read more here.
Keywords: anti inflammatory; triazino quinazolin; inflammatory activity; inflammatory ... See more keywords
Microwave-Assisted Regioselective Synthesis of Variously Functionalized [1,2,4]triazolo[3,4-b]quinazolin-5(1H)-ones
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DOI: 10.2174/1385272824666200814134911
Abstract: [1,2,4]Triazolo[3,4-b]quinazolin-5(1H)-ones with varied functionalization patterns were synthesized in a regioselective manner by reacting 2-thioxo-2,3- dihydroquinazolin-4(1H)-one (2) with variously functionalized hydrazonoyl chlorides (3ah). Linear regioselectivity of the formed products was confirmed by X-ray measurements. Under microwave… read more here.
Keywords: microwave assisted; variously functionalized; triazolo quinazolin; quinazolin ones ... See more keywords
Synthesis and Evaluation of Antioxidant Properties of 2-Substituted Quinazolin-4(3H)-ones
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DOI: 10.3390/molecules26216585
Abstract: Quinazolinones represent an important scaffold in medicinal chemistry with diverse biological activities. Here, two series of 2-substituted quinazolin-4(3H)-ones were synthesized and evaluated for their antioxidant properties using three different methods, namely DPPH, ABTS and TEACCUPRAC,… read more here.
Keywords: substituted quinazolin; antioxidant activity; antioxidant properties; quinazolin ones ... See more keywords
Synthesis, Characterization and Docking Studies of N-Methyl-2, 3-Dihydro Quinazolin-4-Ones Linked 1,3-Thiazole Hybrids as Potent Anti-Tubercular Agents
Sign Up to like & getrecommendations! Published in 2020 at "Indian Journal of Pharmaceutical Sciences"
DOI: 10.36468/pharmaceutical-sciences.730
Abstract: Quinazolin-4-ones connected 1, 3-thiazole were found with antibacterial action after high throughput screening. N-Methyl Anthranilic acid when treated with thiophene-2-carboxylic acid gives 1-Methyl-2- (thiophen-2-yl)-1,2-dihydro-4H-3,1-Benzoxazin-4-one which on further treatment with 4-substituted phenyl-1,3-thiazol-2-amines gives 1-Methyl-3-(4-Substituted phenyl-1,3-thiazol-2yl)-2-(thiophen-2-yl)-2,3- dihydro… read more here.
Keywords: anti tubercular; synthesis characterization; characterization docking; quinazolin ones ... See more keywords