Exploring the Effects of Chirality of 5-methyl-5-[4-(4-oxo-3H-quinazolin-2-yl) phenyl]imidazolidine-2,4-dione and its Derivatives on the Oncological Target Tankyrase 2. Atomistic Insights.
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DOI: 10.2174/1389201024666230330084017
Abstract: BACKGROUND Tankyrases (TNKS) are homomultimers existing in two forms, viz. TNKS1 and TNKS2. TNKS2 plays a pivotal role in carcinogenesis by activating the Wnt//β-catenin pathway. TNKS2 has been identified as a suitable target in oncology… read more here.
Keywords: phenyl imidazolidine; quinazolin phenyl; imidazolidine dione; oxo quinazolin ... See more keywords