Quinazoline-2-Carboxamides as Selective PET Radiotracers for Matrix Metalloproteinase-13 Imaging in Atherosclerosis.
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DOI: 10.1021/acs.jmedchem.2c02107
Abstract: Matrix metalloproteinase-13 (MMP-13) plays a critical role in the progression of unstable atherosclerosis. A series of highly potent and selective MMP-13 inhibitors were synthesized around a quinazoline-2-carboxamide scaffold to facilitate radiolabeling with fluorine-18 or carbon-11… read more here.
Keywords: matrix metalloproteinase; imaging atherosclerosis; atherosclerosis; quinazoline carboxamides ... See more keywords