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Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2967
Abstract: 2-(1H-benzo[d]imidazol-2-yl)anilines reacted with haloketones including 5-chloropentan-2-one and 6-chlorohexan-2-one catalyzed by iodine, giving benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazoline and 6H-benzo[4,5]imidazo[1,2-c]pyrido[1,2-a]quinazoline derivatives, respectively. This domino-type reaction formed two new heterocycles and three new covalent bonds in one-pot procedure and provided a…
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Keywords:
benzo;
benzo imidazo;
quinazoline derivatives;
catalyzed iodine ... See more keywords
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Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2979
Abstract: A series of new 2-aryl-5-methyl-[1,2,4]triazolo[1,5-c]quinazoline derivatives (5a–5g) have been synthesized by the reaction of 3-amino-2-methylquinazolin-4-(3H)-one (3) with aromatic nitriles in potassium tert-butoxide under reflux conditions. 3-Amino-2-methylquinazolin-4-(3H)-one (3) was synthesized by the reaction 2-methyl-4H-benzo[d][1,3]oxazin-4-one (2) with…
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Keywords:
triazolo quinazoline;
synthesis evaluation;
quinazoline derivatives;
evaluation novel ... See more keywords
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2
Published in 2023 at "Pest management science"
DOI: 10.1002/ps.7459
Abstract: BACKGROUND To discover more efficient antimicrobial agents in agriculture, a series of new quinazoline derivatives bearing both sulfonate ester and piperidine-4-carboxamide moieties were synthesized and assessed for their antimicrobial effects. RESULTS All of the target…
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Keywords:
sulfonate ester;
quinazoline derivatives;
compound;
new quinazoline ... See more keywords
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Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.06.026
Abstract: A series of novel quinazoline derivatives containing a dithioacetal moiety were designed and synthesized, and their structures were characterized by 1H nuclear magnetic resonance, 13C nuclear magnetic resonance, and high-resolution mass spectrometry. Bioassay results indicated…
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Keywords:
containing dithioacetal;
derivatives containing;
quinazoline derivatives;
novel quinazoline ... See more keywords
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Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.10.041
Abstract: Despite the recent reductions in the global burden of malaria, this disease remains a devastating cause of death in tropical and subtropical regions. As there is no broadly effective vaccine for malaria, prevention and treatment…
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Keywords:
derivatives potent;
antiplasmodial agents;
quinazoline derivatives;
potent antiplasmodial ... See more keywords
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Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112865
Abstract: Inhibition of PI3Kδ has been proved to be an efficacious strategy for the treatment of hematological malignancies where the PI3K/Akt signaling pathway is hyperactive. Herein, a series of quinazoline derivatives bearing acrylamide fragment were prepared…
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Keywords:
quinazoline derivatives;
novel quinazoline;
discovery novel;
high selectivity ... See more keywords
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Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113794
Abstract: Aberrant activation of the fibroblast growth factor 19-fibroblast growth factor receptor 4 (FGF19-FGFR4) signaling pathway has been proved to promote hepatocellular carcinoma (HCC) proliferation. It is assumed that the first FGFR4 inhibitor BLU9931 did not…
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Keywords:
design synthesis;
biological evaluation;
evaluation quinazoline;
quinazoline derivatives ... See more keywords
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Published in 2021 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2021.121847
Abstract: Abstract In recent years, a lot of benefits of Selenium have been discovered for humans, animals and chemical uses. Nano-Selenium was biosynthesized and characterized by using FTIR, UV/Vis., TEM/SAED, and mapping to ensure their crystallinity.…
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Keywords:
catalyst;
quinazoline derivatives;
trpv1 inhibitor;
selenium ... See more keywords
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Published in 2020 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2020.152508
Abstract: Abstract A tandem cyclization reaction of diethyl 2-(2-aminobenzamido)malonates and 2-bromobenzaldehydes was developed for the synthesis of isoindolo[1,2-b]quinazoline derivatives. The quinazoline was formed first catalyzed by CuI, followed by a noteworthy α-arylation reaction under Pd and…
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Keywords:
free conditions;
ligand free;
isoindolo quinazoline;
quinazoline derivatives ... See more keywords
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Published in 2020 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520620666200627205321
Abstract: BACKGROUND Cancer is one of the major causes of worldwide human mortality. A number of existing antineoplastic medications and treatment regimens are already working in the field and several new compounds are in different phases…
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Keywords:
quinazoline;
chemistry;
quinazoline derivatives;
quinazoline scaffold ... See more keywords
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2
Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076851
Abstract: Aberrant expression of the phosphatidylinositol 3-kinase (PI3K) signalling pathway is often associated with tumourigenesis, progression and poor prognosis. Hence, PI3K inhibitors have attracted significant interest for the treatment of cancer. In this study, a series…
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Keywords:
pi3k;
quinazoline derivatives;
imidazo pyridin;
pyridin quinazoline ... See more keywords