An Efficient Synthesis of Pyrrolo[1,2‐a] or Pyrido[1,2‐a]benzo[4,5]imidazo[1,2‐c]quinazoline Derivatives in Ionic Liquids Catalyzed by Iodine
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2967
Abstract: 2-(1H-benzo[d]imidazol-2-yl)anilines reacted with haloketones including 5-chloropentan-2-one and 6-chlorohexan-2-one catalyzed by iodine, giving benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazoline and 6H-benzo[4,5]imidazo[1,2-c]pyrido[1,2-a]quinazoline derivatives, respectively. This domino-type reaction formed two new heterocycles and three new covalent bonds in one-pot procedure and provided a… read more here.
Keywords: benzo; benzo imidazo; quinazoline derivatives; catalyzed iodine ... See more keywords
Synthesis and Evaluation of Novel [1,2,4]Triazolo[1,5‐c]quinazoline Derivatives as Antibacterial Agents
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DOI: 10.1002/jhet.2979
Abstract: A series of new 2-aryl-5-methyl-[1,2,4]triazolo[1,5-c]quinazoline derivatives (5a–5g) have been synthesized by the reaction of 3-amino-2-methylquinazolin-4-(3H)-one (3) with aromatic nitriles in potassium tert-butoxide under reflux conditions. 3-Amino-2-methylquinazolin-4-(3H)-one (3) was synthesized by the reaction 2-methyl-4H-benzo[d][1,3]oxazin-4-one (2) with… read more here.
Keywords: triazolo quinazoline; synthesis evaluation; quinazoline derivatives; evaluation novel ... See more keywords
Design, synthesis, crystal structure, and antimicrobial activities of new quinazoline derivatives containing both the sulfonate ester and piperidinylamide moieties.
Sign Up to like & getrecommendations! Published in 2023 at "Pest management science"
DOI: 10.1002/ps.7459
Abstract: BACKGROUND To discover more efficient antimicrobial agents in agriculture, a series of new quinazoline derivatives bearing both sulfonate ester and piperidine-4-carboxamide moieties were synthesized and assessed for their antimicrobial effects. RESULTS All of the target… read more here.
Keywords: sulfonate ester; quinazoline derivatives; compound; new quinazoline ... See more keywords
Syntheses, antiviral activities and induced resistance mechanisms of novel quinazoline derivatives containing a dithioacetal moiety.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.06.026
Abstract: A series of novel quinazoline derivatives containing a dithioacetal moiety were designed and synthesized, and their structures were characterized by 1H nuclear magnetic resonance, 13C nuclear magnetic resonance, and high-resolution mass spectrometry. Bioassay results indicated… read more here.
Keywords: containing dithioacetal; derivatives containing; quinazoline derivatives; novel quinazoline ... See more keywords
Identification of novel quinazoline derivatives as potent antiplasmodial agents.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.10.041
Abstract: Despite the recent reductions in the global burden of malaria, this disease remains a devastating cause of death in tropical and subtropical regions. As there is no broadly effective vaccine for malaria, prevention and treatment… read more here.
Keywords: derivatives potent; antiplasmodial agents; quinazoline derivatives; potent antiplasmodial ... See more keywords
Discovery of novel quinazoline derivatives as potent PI3Kδ inhibitors with high selectivity.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112865
Abstract: Inhibition of PI3Kδ has been proved to be an efficacious strategy for the treatment of hematological malignancies where the PI3K/Akt signaling pathway is hyperactive. Herein, a series of quinazoline derivatives bearing acrylamide fragment were prepared… read more here.
Keywords: quinazoline derivatives; novel quinazoline; discovery novel; high selectivity ... See more keywords
Design, synthesis and biological evaluation of quinazoline derivatives as potent and selective FGFR4 inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113794
Abstract: Aberrant activation of the fibroblast growth factor 19-fibroblast growth factor receptor 4 (FGF19-FGFR4) signaling pathway has been proved to promote hepatocellular carcinoma (HCC) proliferation. It is assumed that the first FGFR4 inhibitor BLU9931 did not… read more here.
Keywords: design synthesis; biological evaluation; evaluation quinazoline; quinazoline derivatives ... See more keywords
Biosynthesized Selenium nanoparticles as a new catalyst in the synthesis of quinazoline derivatives in pentacyclic system with docking validation as (TRPV1) inhibitor
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2021.121847
Abstract: Abstract In recent years, a lot of benefits of Selenium have been discovered for humans, animals and chemical uses. Nano-Selenium was biosynthesized and characterized by using FTIR, UV/Vis., TEM/SAED, and mapping to ensure their crystallinity.… read more here.
Keywords: catalyst; quinazoline derivatives; trpv1 inhibitor; selenium ... See more keywords
Copper(I)-catalyzed synthesis of isoindolo[1,2-b]quinazoline derivatives via an α-arylation under Pd and ligand free conditions
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DOI: 10.1016/j.tetlet.2020.152508
Abstract: Abstract A tandem cyclization reaction of diethyl 2-(2-aminobenzamido)malonates and 2-bromobenzaldehydes was developed for the synthesis of isoindolo[1,2-b]quinazoline derivatives. The quinazoline was formed first catalyzed by CuI, followed by a noteworthy α-arylation reaction under Pd and… read more here.
Keywords: free conditions; ligand free; isoindolo quinazoline; quinazoline derivatives ... See more keywords
Design, Synthesis, and Evaluation of 8-(o-Tolyl)quinazoline Derivatives as Small-Molecule PD-1/PD-L1 Antagonists.
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DOI: 10.1021/acsmedchemlett.4c00014
Abstract: Small-molecule inhibitors targeting programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) interactions can compensate for the shortcomings of antibody-based inhibitors and have attracted considerable attention, some of which have already entered clinical trials. Herein, based on… read more here.
Keywords: molecule; tolyl quinazoline; quinazoline derivatives; small molecule ... See more keywords
SynthesIs, antiproliferative evaluation and in silico studies of new quinazoline derivatives as VEGFR-2 inhibitors.
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DOI: 10.1080/17568919.2025.2525073
Abstract: BACKGROUND New quinazoline derivatives were designed and synthesized to target VEGFR-2, aiming to identify potential anticancer agents. RESEARCH DESIGN AND METHODS The synthesized compounds underwent in vitro screening to evaluate their cytotoxic effects across 60… read more here.
Keywords: new quinazoline; quinazoline derivatives; vegfr inhibitory; cell ... See more keywords