A Benzannulation Strategy for Rapid Access to Quinazoline-2,4-diones via Oxidative N-Heterocyclic Carbene Catalysis.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00954
Abstract: N-Heterocyclic carbene-catalyzed formal [4+2] benzannulation of enals with suitably substituted pyrimidine-2,4-diones allowing the mild and facile synthesis of functionalized quinazoline-2,4-diones is presented. This oxidative transformation proceeds via the simultaneous generation of dienolates and α,β-unsaturated acylazoliums… read more here.
Keywords: benzannulation strategy; strategy rapid; quinazoline diones; heterocyclic carbene ... See more keywords
Synthesis of N-Unsubstituted and N3-Substituted Quinazoline-2,4(1H,3H)-diones from o-Aminobenzamides and CO2 at Atmospheric Pressure and Room Temperature.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00614
Abstract: The unprecedented metal-free synthesis of both N-unsubstituted and N3-substituted quinazoline-2,4(1H,3H)-diones from o-aminobenzamides and CO2 under atmospheric pressure at room temperature is developed. This protocol easily allows for variations of functional groups (including alkyl, aryl, and… read more here.
Keywords: substituted quinazoline; unsubstituted substituted; synthesis unsubstituted; diones aminobenzamides ... See more keywords
Indole-Containing Pyrazino[2,1-b]quinazoline-3,6-diones Active against Plasmodium and Trypanosomatids.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.1c00589
Abstract: Malaria, leishmaniasis, and sleeping sickness are potentially fatal diseases that represent a real health risk for more than 3,5 billion people. New antiparasitic compounds are urgent leading to a constant search for novel scaffolds. Herein,… read more here.
Keywords: quinazoline diones; plasmodium; activity; indole containing ... See more keywords
Octahydropyrimido[4,5-g]quinazoline-5,10-diones: their multicomponent synthesis, self-assembly on graphite and electrochemistry.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc02070j
Abstract: A green multicomponent synthesis of previously unreported octahydropyrimido[4,5-g]quinazoline-5,6-diones was developed from simple building blocks. These highly symmetrical compounds show strong propensity to self-assembled molecular network (SAMN) formation on highly oriented pyrolytic graphite. The SAMN type… read more here.
Keywords: multicomponent synthesis; electrochemistry; quinazoline diones; octahydropyrimido quinazoline ... See more keywords
Palladium-Catalyzed Oxidative Cycloaddition of Quinazoline-2,4(1H,3H)-diones and Diarylalkynes via C-H/N-H Activation
Sign Up to like & getrecommendations! Published in 2023 at "Synthesis"
DOI: 10.1055/a-2105-2850
Abstract: The oxidative cycloaddition of 3-subsituted quinazoline-2,4(1H,3H)-diones and alkynes has been developed. The reaction is Pd(II)-catalyzed and successfully occurs in the presence of Ag(I) oxidants. This transformation is assumed to proceed by N-H palladation of the… read more here.
Keywords: oxidative cycloaddition; palladium catalyzed; quinazoline; quinazoline diones ... See more keywords