A New Route for the Synthesis of (Trichloromethyl)Quinazoline‐4(1H)‐One and (1,2,3‐Triazole)‐Quinazoline‐4(1H)‐One Functionalized Derivatives via Copper‐Catalyzed One‐Pot Multicomponent Reactions
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.4899
Abstract: The synthesis of functionalized (trichloromethyl)quinazoline‐4(1H)‐one with high yields through a novel three‐component intramolecular CH activation reaction from trichloroacetonitrile, benzoyl chlorides, and various primary amines is a remarkable achievement in organic chemistry. This strategy offers a… read more here.
Keywords: chemistry; quinazoline; triazole quinazoline; synthesis ... See more keywords
Design, synthesis, and antiproliferative activity of new 1,2,3-triazole/quinazoline-4-one hybrids as dual EGFR/BRAFV600E inhibitors
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DOI: 10.1039/d4ra06694d
Abstract: A novel series of 1,2,3-triazole/quinazoline-4-one hybrids (8a–t) were designed and synthesized as dual-targeted antiproliferative agents. Compounds 8a–t were evaluated for their antiproliferative efficacy against a panel of four cancer cell lines. The results indicated that… read more here.
Keywords: one hybrids; brafv600e inhibitors; triazole quinazoline; egfr brafv600e ... See more keywords
Design and synthesis of new 1,2,4-oxadiazole/quinazoline-4-one hybrids with antiproliferative activity as multitargeted inhibitors
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2024.1447618
Abstract: Introduction The combination of BRAF and tyrosine kinase (TK) inhibitors has been demonstrated to be highly effective in inhibiting tumor development and is an approach for overcoming resistance in clinical trials. Accordingly, a novel series… read more here.
Keywords: one hybrids; oxadiazole quinazoline; antiproliferative agents; quinazoline one ... See more keywords