Synthesis and biological evaluation of novel quinazoline-4-piperidinesulfamide derivatives as inhibitors of NPP1.
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DOI: 10.1016/j.ejmech.2018.01.094
Abstract: The ecto-nucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) was recently shown to promote mineralization of the aortic valve, hence, its inhibition represents a significant target. A quinazoline-4-piperidine sulfamide compound (QPS1) has been described as a specific and non-competitive inhibitor… read more here.
Keywords: quinazoline piperidinesulfamide; evaluation novel; biological evaluation; piperidinesulfamide derivatives ... See more keywords