A one-pot synthetic approach for the construction of a thiazolo[3,2-a]benzimidazole-linked quinazoline scaffold via palladium-catalyzed reactions
Sign Up to like & getrecommendations! Published in 2018 at "Organic chemistry frontiers"
DOI: 10.1039/c7qo00751e
Abstract: 4-(2-Substituted-[1,3]thiazolo[3,2-a]benzimidazol-3-yl)quinazolin-2-amines were prepared by the multi-component reaction of 2,4-dichloroquinazoline, terminal alkynes, secondary amines, and 1H-benzo[d]imidazole-2(3H)-thione in the presence of a palladium–copper catalyst. This one-pot process provided an efficient and successful approach for the synthesis of… read more here.
Keywords: thiazolo benzimidazole; linked quinazoline; benzimidazole linked; one pot ... See more keywords
Bestowal of Quinazoline Scaffold in Anticancer Drug Discovery.
Sign Up to like & getrecommendations! Published in 2020 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520620666200627205321
Abstract: BACKGROUND Cancer is one of the major causes of worldwide human mortality. A number of existing antineoplastic medications and treatment regimens are already working in the field and several new compounds are in different phases… read more here.
Keywords: quinazoline; chemistry; quinazoline derivatives; quinazoline scaffold ... See more keywords