Design, synthesis, anticancer, and antibacterial evaluation of some quinazolinone-based derivatives as DHFR inhibitors.
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DOI: 10.1002/ddr.22060
Abstract: Two series of quinazolinone derivatives were designed and synthesized as dihydrofolate reductase (DHFR) inhibitors. All compounds were evaluated for their antibacterial and antitumor activities. Antibacterial activity was evaluated against three strains of Gram-positive and Gram-negative… read more here.
Keywords: quinazolinone; compound; ccrf cem; activity ... See more keywords
Synthesis, characterization and biological activity of new 3(4H)-quinazolinone derivatives
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DOI: 10.1134/s1070363217090237
Abstract: Quinazolinylbenzoic acid 1 was used as a precursor for synthesis of many heterocyclic systems. Ethyl 4-[4-oxo-2-phenylquinazolin-3(4H)-yl]benzoate 2 upon reaction with hydrazine hydrate gave 4-[4-oxo-2-phenylquinazolin-3(4H)-yl]benzoate benzoylhydrazide 3. Compound 3 on treatment with 3-nitrobenzaldehyde, acetyl acetone, ethyl… read more here.
Keywords: quinazolinone derivatives; biological activity; characterization biological; quinazolinone ... See more keywords
Synthesis and anticancer activity of novel quinazolinone-based rhodanines
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DOI: 10.1186/s13065-017-0333-x
Abstract: BackgroundRhodanines and quinazolinones have been reported to possess various pharmacological activities.ResultsA novel series of twenty quinazolinone-based rhodanines were synthesized via Knoevenagel condensation between 4-[3-(substitutedphenyl)-3,4-dihydro-4-oxoquinazolin-2-yl)methoxy]substituted-benzaldehydes and rhodanine. Elemental and spectral analysis were used to confirm structures… read more here.
Keywords: quinazolinone; based rhodanines; synthesis anticancer; quinazolinone based ... See more keywords
The antibacterial activity of quinazoline and quinazolinone hybrids.
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DOI: 10.2174/1568026622666220307144015
Abstract: Bacterial infections cause substantial morbidity and mortality across the world and pose serious threats to humankind. Drug resistance, especially multidrug resistance resulting from different defensive mechanisms in bacteria, is the leading cause of failure the… read more here.
Keywords: quinazolinone; quinazoline quinazolinone; antibacterial activity; activity quinazoline ... See more keywords
Study of the anticancer effect of new quinazolinone hydrazine derivatives as receptor tyrosine kinase inhibitors
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DOI: 10.3389/fchem.2022.969559
Abstract: The advent of novel receptor tyrosine kinase inhibitors has provided an important therapeutic tool for cancer patients. In this study, a series of quinazolinone hydrazide triazole derivatives were designed and synthesized as novel MET (c-MET)… read more here.
Keywords: quinazolinone; effect; kinase inhibitors; receptor tyrosine ... See more keywords