Design and synthesis of novel quinazolinone-based derivatives as EGFR inhibitors with antitumor activity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2118735
Abstract: Abstract Nineteen new quinazolin-4(3H)-one derivatives 3a–g and 6a–l were designed and synthesised to inhibit EGFR. The antiproliferative activity of the synthesised compounds was tested in vitro against 60 different human cell lines. The most potent… read more here.
Keywords: design synthesis; cell; novel quinazolinone; activity ... See more keywords
Synthesis and anticancer activity of novel quinazolinone-based rhodanines
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DOI: 10.1186/s13065-017-0333-x
Abstract: BackgroundRhodanines and quinazolinones have been reported to possess various pharmacological activities.ResultsA novel series of twenty quinazolinone-based rhodanines were synthesized via Knoevenagel condensation between 4-[3-(substitutedphenyl)-3,4-dihydro-4-oxoquinazolin-2-yl)methoxy]substituted-benzaldehydes and rhodanine. Elemental and spectral analysis were used to confirm structures… read more here.
Keywords: quinazolinone; based rhodanines; synthesis anticancer; quinazolinone based ... See more keywords