Design, Synthesis, Antibacterial Evaluation, Three-Dimensional Quantitative Structure-Activity Relationship, and Mechanism of Novel Quinazolinone Derivatives.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c07264
Abstract: Plant bacterial illnesses are common and cause dramatic damage to agricultural goods all over the world, yet there are few efficient bactericides to alleviate them at present. To discover novel antibacterial agents, two series of… read more here.
Keywords: design synthesis; mechanism; quinazolinone derivatives; antibacterial evaluation ... See more keywords
Aryl Quinazolinone Derivatives as Novel Therapeutic Agents against Brain-Eating Amoebae.
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DOI: 10.1021/acschemneuro.9b00596
Abstract: Naegleria fowleri and Balamuthia mandrillaris are protist pathogens that infect the central nervous system, causing primary amoebic meningoencephalitis and granulomatous amoebic encephalitis with mortality rates of over 95%. Quinazolinones and their derivatives possess a wide… read more here.
Keywords: quinazolinone derivatives; eating amoebae; derivatives novel; aryl quinazolinone ... See more keywords
Design, synthesis, biological activities and 3D-QSAR studies of quinazolinone derivatives containing hydrazone structural units
Sign Up to like & getrecommendations! Published in 2021 at "New Journal of Chemistry"
DOI: 10.1039/d0nj05450j
Abstract: In this study, three series of quinazolinone derivatives containing hydrazone structures were designed and synthesized. Bioactivity assays indicated that these compounds showed good antitumour activities towards human lung cancer cells (A549) and human prostate cancer… read more here.
Keywords: design synthesis; structural units; containing hydrazone; biological activities ... See more keywords
Synthesis, characterization and biological activity of new 3(4H)-quinazolinone derivatives
Sign Up to like & getrecommendations! Published in 2017 at "Russian Journal of General Chemistry"
DOI: 10.1134/s1070363217090237
Abstract: Quinazolinylbenzoic acid 1 was used as a precursor for synthesis of many heterocyclic systems. Ethyl 4-[4-oxo-2-phenylquinazolin-3(4H)-yl]benzoate 2 upon reaction with hydrazine hydrate gave 4-[4-oxo-2-phenylquinazolin-3(4H)-yl]benzoate benzoylhydrazide 3. Compound 3 on treatment with 3-nitrobenzaldehyde, acetyl acetone, ethyl… read more here.
Keywords: quinazolinone derivatives; biological activity; characterization biological; quinazolinone ... See more keywords
Quinazolinone Derivatives Loaded Polypyrrole/Chitosan Core–Shell Nanoparticles with Different Morphologies: Antibacterial and Anticancer Activities
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DOI: 10.1142/s1793292017500023
Abstract: Polypyrrole/chitosan (PPC) spherical dark nanoparticles surrounded by shadow spheres were fabricated through in situ oxidative polymerization of pyrrole in presence of chitosan (CS) using ferric chloride (FeCl3) as oxidant and evaluated as a carrier for… read more here.
Keywords: quinazolinone derivatives; core shell; shell nanoparticles; chitosan ... See more keywords
An insight on the prospect of quinazoline and quinazolinone derivatives as anti-tubercular agents.
Sign Up to like & getrecommendations! Published in 2023 at "Current organic synthesis"
DOI: 10.2174/1570179420666230316094435
Abstract: Multiple potential drugs have been developed based on the heterocyclic molecules for the treatment of different symptoms. Among the existing heterocyclic molecules, quinazoline and quinazolinone derivatives have been found to exhibit extensive pharmacological and biological… read more here.
Keywords: anti tubercular; quinazoline quinazolinone; quinazolinone derivatives; insight prospect ... See more keywords
Synthesis and cytotoxic evaluation of novel quinazolinone derivatives as potential anticancer agents
Sign Up to like & getrecommendations! Published in 2018 at "Research in Pharmaceutical Sciences"
DOI: 10.4103/1735-5362.236838
Abstract: Nitrogen-rich heterocyclic compounds represent a unique class of chemicals with especial properties and have been modified to design novel pharmaceutically active compounds. In this study, a series of novel quinazolinone derivatives with substituted quinoxalindione were… read more here.
Keywords: quinazolinone derivatives; novel quinazolinone; cell lines; cytotoxic evaluation ... See more keywords