P‐Glycoprotein and Breast Cancer Resistance Protein Transporter Inhibition by Cyclosporine and Quinidine on the Pharmacokinetics of Oral Rimegepant in Healthy Subjects
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DOI: 10.1002/cpdd.1088
Abstract: Rimegepant (Nurtec ODT)—an orally administered, small‐molecule calcitonin gene–related peptide receptor antagonist indicated for the acute and preventive treatment of migraine—is a substrate for both the P‐glycoprotein and breast cancer resistance protein transporters in vitro. We… read more here.
Keywords: breast cancer; resistance protein; quinidine; cancer resistance ... See more keywords
Modelling the effects of quinidine, disopyramide, and E-4031 on short QT syndrome variant 3 in the human ventricles.
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DOI: 10.1088/1361-6579/aa8695
Abstract: OBJECTIVE Short QT syndrome (SQTS) is an inherited cardiac channelopathy, but at present little information is available on its pharmacological treatment. SQT3 variant (linked to the inward rectifier potassium current I K1) of SQTS, results… read more here.
Keywords: effects quinidine; short syndrome; disopyramide 4031; quinidine ... See more keywords
6081Efficacy and limitations of quinidine therapy in patients with Brugada Syndrome
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DOI: 10.1093/eurheartj/ehz746.0125
Abstract: Quinidine at high-dose is used in patients with Brugada Syndrome (BrS), but its efficacy to prevent life-threatening arrhythmic events (LAE) in BrS is unproven and its use is limited by side effects. We assessed whether… read more here.
Keywords: brs; brs patients; patients brugada; quinidine ... See more keywords
Low‐Dose Quinidine Effectively Reduced Shocks in Brugada Syndrome Patients with an Implantable Cardioverter Defibrillator: A Chinese Case Series Report
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DOI: 10.1111/anec.12375
Abstract: Only implantable cardioverter defibrillators (ICD) have been proven to prevent sudden cardiac death (SCD) in patients with Brugada syndrome (BrS). However, ICD discharge, whether appropriate or inappropriate, leads to impaired quality of life and even… read more here.
Keywords: dose quinidine; low dose; quinidine effectively; quinidine ... See more keywords
Efficacy and Tolerability of Quinidine as Salvage Therapy for Monomorphic Ventricular Tachycardia in patients with Structural Heart Disease.
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DOI: 10.1111/jce.15260
Abstract: INTRODUCTION Quinidine is an effective therapy for a subset of polymorphic ventricular tachycardia and ventricular fibrillation (VF) syndromes, however the efficacy of quinidine in scar related monomorphic ventricular tachycardia (MMVT) is unclear. METHODS AND RESULTS… read more here.
Keywords: monomorphic ventricular; ventricular tachycardia; structural heart; quinidine ... See more keywords