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   Articles with "quinolin ones" as a keyword



2H-Pyrano[3,2-c]quinolin-2-ones: their convenient synthesis and selected reactions

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recommendations! Published in 2017 at "Chemical Papers"

DOI: 10.1007/s11696-017-0319-0

Abstract: Despite the structure attractiveness of 2H-pyrano[3,2-c]quinolin-2-ones 3 their synthesis is not sufficiently developed. Only 35 pyranoquinolinones 3 are registered in the SciFinder database. Unavailability of 3 limits their chemistry exploitation, physical and biological studies. We… read more here.

Keywords: methodology; quinolin ones; chemistry; pyrano quinolin ... See more keywords

Novel access to 2-substituted quinolin-4-ones by nickel boride-mediated reductive ring transformation of 5-(2-nitrophenyl)isoxazoles

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recommendations! Published in 2019 at "Tetrahedron Letters"

DOI: 10.1016/j.tetlet.2019.151327

Abstract: Abstract Reductive ring transformation of 3-substituted 5-(2-nitrophenyl)isoxazoles, readily accessible via 1,3-dipolar cycloaddition of 2-ethinylnitrobenzene with nitrile oxides, opens a novel access to 2-substituted quinolin-4-ones. Nickel boride, generated in situ from nickel chloride and sodium borohydride,… read more here.

Keywords: quinolin ones; reductive ring; nitrophenyl isoxazoles; ring transformation ... See more keywords

6-Benzhydryl-4-amino-quinolin-2-ones as Potent Cannabinoid Type 1 (CB1) Receptor Inverse Agonists and Chemical Modifications for Peripheral Selectivity.

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recommendations! Published in 2018 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.8b01467

Abstract: A novel series of 6-benzhydryl-4-amino-quinolin-2-ones was discovered as cannabinoid type 1 receptor (CB1R) inverse agonists based on the high-throughput screening hit, compound 1a. Structure-activity relationships were studied to improve in vitro/in vivo pharmacology and restrict… read more here.

Keywords: amino quinolin; cannabinoid type; benzhydryl amino; quinolin ones ... See more keywords
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Catalytic Asymmetric Hydrogenation of 3-Ethoxycarbonyl Quinolin-2-ones and Coumarins.

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recommendations! Published in 2021 at "Organic letters"

DOI: 10.1021/acs.orglett.1c00993

Abstract: A protocol of iridium catalyzed asymmetric hydrogenation of 4-alkyl substituted 3-ethoxycarbonyl quinolin-2-ones and coumarins has been reported, providing a wide range of chiral dihydroquinolin-2-ones and dihydrocoumarins in high yields with excellent enantioselectivities (up to 99%… read more here.

Keywords: ethoxycarbonyl quinolin; asymmetric hydrogenation; quinolin ones; ones coumarins ... See more keywords

Temperature Tunable Synthesis of Tetrahydro-4H-pyrrolo[3,2-c]quinolin-4-ones and Dihydro-1H-benzo[b]azepines from 2-Aminobenzonitriles and Donor-Acceptor Cyclopropanes.

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recommendations! Published in 2022 at "Organic letters"

DOI: 10.1021/acs.orglett.2c03674

Abstract: Tetrahydro-4H-pyrrolo[3,2-c]quinolin-4-ones and dihydro-1H-benzo[b]azepines are efficiently synthesized from 2-aminobenzonitriles and donor-acceptor cyclopropanes mediated by SnCl4 in moderate to good yields. The reaction involves the initial ring opening of a cyclopropane ring due to activation by SnCl4… read more here.

Keywords: tetrahydro pyrrolo; ones dihydro; benzo azepines; dihydro benzo ... See more keywords

The [4+2] Annulation of o-Acylamino-aryl MBH Carbonates with Coumarins: Facile Access to Tetrahydrochromeno[4,3-b]quinolin-6-ones

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recommendations! Published in 2025 at "New Journal of Chemistry"

DOI: 10.1039/d4nj04654d

Abstract: The [4+2] annulation reaction of o-acylamino-aryl MBH carbonates with 3-substituted coumarins has been developed. This method exhibits excellent substrate tolerance and constructs a series of tetrahydrochromeno[4,3-b]quinolin-6-ones with yields up to... read more here.

Keywords: annulation; tetrahydrochromeno quinolin; acylamino aryl; aryl mbh ... See more keywords

Easy Access to Quinolin-2(1H)-ones via a One-Pot Tandem Oxa-Michael–Aldol Sequence

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recommendations! Published in 2017 at "Synlett"

DOI: 10.1055/s-0036-1588470

Abstract: An efficient strategy for the synthesis of a variety of quinolin-2(1H)-one derivatives has been developed. The reaction proceeded from cinnamide derivatives via a tandem reaction in the presence of NaOH to afford the corresponding 2-… read more here.

Keywords: easy access; quinolin ones; access quinolin; ones via ... See more keywords

Photoinduced radical tandem annulation of 1,7-diynes: an approach for divergent assembly of functionalized quinolin-2(1H)-ones

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recommendations! Published in 2024 at "Frontiers in Chemistry"

DOI: 10.3389/fchem.2024.1371978

Abstract: The first photocatalytic trichloromethyl radical-triggered annulative reactions of amide-linked 1,7-diynes with polyhalomethanes were established for the flexible assembly of functionalized quinolin-2(1H)-ones with generally acceptable yields. With the installation of the aryl group (R1) into the… read more here.

Keywords: radical tandem; assembly functionalized; functionalized quinolin; tandem annulation ... See more keywords