Repurposing of quinoline alkaloids identifies their ability to enhance doxorubicin‐induced sub‐G0/G1 phase cell cycle arrest and apoptosis in cervical and hepatocellular carcinoma cells
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1999
Abstract: The ability of quinoline alkaloids (cinchonine, cinchonidine, quinine, and quinidine) to sensitize different human cancer cell lines to doxorubicin (DOX)‐induced cell death was evaluated. Cell viability was analyzed using 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay and the… read more here.
Keywords: dox induced; quinoline alkaloids; apoptosis; ability ... See more keywords
Bioactive carbazole and quinoline alkaloids from Clausena dunniana.
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DOI: 10.1016/j.phytochem.2018.03.009
Abstract: Nine undescribed carbazole and quinoline alkaloids, named dunnines A-E, and 14 known analogues were isolated from the leaves and stems of Clausena dunniana. Their structures were elucidated on the basis of comprehensive analysis of NMR… read more here.
Keywords: carbazole quinoline; quinoline alkaloids; bioactive carbazole; clausena dunniana ... See more keywords
Anti-inflammatory Quinoline Alkaloids from the Roots of Waltheria indica.
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DOI: 10.1021/acs.jnatprod.2c00861
Abstract: Sixteen new quinoline alkaloids (1a-7, 8a, 9, 10, 13-15, 17, and 21) and 10 known analogs (8b, 11, 12, 16, 18-20, and 22-24), along with three known cyclopeptide alkaloids (25-27), were isolated from the roots… read more here.
Keywords: waltheria indica; inhibition; quinoline alkaloids; anti inflammatory ... See more keywords
Cage-Monoterpenoid Quinoline Alkaloids with Neurite Growth Promoting Effects from the Fruits of Melodinus yunnanensis.
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DOI: 10.1021/acs.orglett.0c02871
Abstract: Meloyunnanines A-C, three alkaloids with an unprecedented skeleton, were isolated from fruits of Melodinus yunnanensis. The structures featuring a caged-6/6/5/6/5/5 ring system were elucidated by the analysis of comprehensive spectroscopic and X-ray data. Biosynthetically, meloyunnanines… read more here.
Keywords: fruits melodinus; melodinus yunnanensis; quinoline alkaloids; monoterpenoid quinoline ... See more keywords