Synthesis and biological evaluation of new quinoline‐4‐carboxylic acid‐chalcone hybrids as dihydroorotate dehydrogenase inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200374
Abstract: Fourteen novel quinoline‐4‐carboxylic acid‐chalcone hybrids were obtained via Claisen–Schmidt condensation and evaluated as potential human dihydroorotate dehydrogenase (hDHODH) inhibitors. The ketone precursor 2 was synthesized by the Pfitzinger reaction and used for further derivatization at… read more here.
Keywords: carboxylic acid; acid chalcone; chalcone hybrids; dihydroorotate dehydrogenase ... See more keywords
A green multicomponent approach for the synthesis of 4-quinoline carboxylic acid via modified Doebner hydrogen transfer reaction
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DOI: 10.1080/17518253.2025.2525112
Abstract: ABSTRACT A modified, eco-friendly, and efficient one-pot multicomponent Doebner hydrogen transfer strategy has been developed to produce 4-quinoline carboxylic acid. This improved method offers several significant advantages, including simple and mild reaction conditions, excellent conversion… read more here.
Keywords: reaction; hydrogen transfer; multicomponent; doebner hydrogen ... See more keywords
Quinoline-3-Carboxylic Acids "DNA Minor Groove-Binding Agent.
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DOI: 10.2174/1871520621666210513160714
Abstract: BACKGROUND The lead compounds from the series of 2, 4-disubstituted quinoline-3-carboxylic acid derivatives were selected for the in-silico mechanistic study. The compounds were found selective and potent for the cancer cell. Moreover, the relevant ADME… read more here.
Keywords: dna; study; minor groove; binding ... See more keywords
In silico target identification and pharmacokinetic profiling of 2-aryl-quinoline-4-carboxylic acid derivatives as potential antileishmanial agents
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DOI: 10.3389/fphar.2025.1621059
Abstract: Introduction Leishmaniasis remains a major neglected tropical disease, and new therapeutic strategies are urgently needed. This study aimed to identify the molecular target of 2-aryl-quinoline-4-carboxylic acid derivatives and assess their pharmacokinetic profiles. Methods An integrated… read more here.
Keywords: aryl quinoline; quinoline carboxylic; target; carboxylic acid ... See more keywords