Discovery of Novel Quinoline-Chalcone Derivatives as Potent Antitumor Agents with Microtubule Polymerization Inhibitory Activity.
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DOI: 10.1021/acs.jmedchem.8b01755
Abstract: A series of novel quinoline-chalcone derivatives were designed, synthesized, and evaluated for their antiproliferative activity. Among them, compound 24d exhibited the most potent activity with IC50 values ranging from 0.009 to 0.016 μM in a… read more here.
Keywords: chalcone derivatives; quinoline chalcone; novel quinoline; discovery novel ... See more keywords