Rational Optimization of Dihydropyrimidinone‐Quinoline Hybrids as Plasmodium falciparum Glutathione Reductase Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200034
Abstract: A series of dihydropyrimidinone‐based antimalarial compounds were designed and synthesised based on the previously identified amide‐based quinoline hybrids which showed good resistance reversal ability against the resistant strain of Plasmodium falciparum. The aromatic ring on… read more here.
Keywords: plasmodium falciparum; glutathione reductase; dihydropyrimidinone; falciparum glutathione ... See more keywords
Steroid-Quinoline Hybrids for Disruption and Reversion of Protein Aggregation Processes.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.1c00604
Abstract: Reversing protein aggregation within cells may be an important tool to fight protein-misfolding disorders such as Alzheimer's, Parkinson's, and cardiovascular diseases. Here we report the design and synthesis of a family of steroid-quinoline hybrid compounds… read more here.
Keywords: aggregation; steroid quinoline; quinoline hybrids; protein aggregation ... See more keywords
Microwave-assisted synthesis of pharmacologically active 4-phenoxyquinolines and their benzazole-quinoline hybrids through SNAr reaction of 4,7-dichloroquinoline and phenols using [bmim][PF6] as a green solvent.
Sign Up to like & getrecommendations! Published in 2022 at "Current organic synthesis"
DOI: 10.2174/1570179419666220830090614
Abstract: BACKGROUND Quinoline and its derivatives have been shown to display a wide spectrum of biological properties, especially anticancer activity. Particularly, diverse potent anticancer drugs are based on the 4-phenoxyquinoline skeleton, acting as small-molecules VEGR2 and/or… read more here.
Keywords: reaction; bmim pf6; synthesis; benzazole quinoline ... See more keywords
Recent Updates on Synthesis, Biological Activity, and Structure-Activity Relationship of 1,3,4-oxadiazole-Quinoline Hybrids: A Review.
Sign Up to like & getrecommendations! Published in 2022 at "Current organic synthesis"
DOI: 10.2174/1570179420666221004142659
Abstract: Due to their diverse applications in industrial and synthetic organic chemistry, quinoline and 1,3,4-oxadiazole have become important heterocyclic compounds. Quinoline and 1,3,4-oxadiazole compounds have been developed for various medical conditions such as anti-cancer, anti-bacterial, anti-fungal,… read more here.
Keywords: structure activity; oxadiazole quinoline; activity relationship; activity ... See more keywords