NOVEL HYBRIDS OF QUINOLINE LINKED PYRIMIDINE DERIVATIVES AS CYCLOOXYGENASE INHIBITORS: MOLECULAR DOCKING, ADMET STUDY, AND MD SIMULATION
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Applied Pharmaceutics"
DOI: 10.22159/ijap.2024v16i6.52023
Abstract: Objective: Finding novel anti-inflammatory compounds is a crucial sector of research despite the significant advances this field has made. Inefficiency and unfavorable side effects are indeed potential drawbacks of conventional therapy utilizing steroidal or nonsteroidal… read more here.
Keywords: linked pyrimidine; pyrimidine derivatives; quinoline linked; derivatives cyclooxygenase ... See more keywords
Benzamides Substituted with Quinoline-Linked 1,2,4-Oxadiazole: Synthesis, Biological Activity and Toxicity to Zebrafish Embryo
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DOI: 10.3390/molecules27123946
Abstract: To develop new compounds with high activity, broad spectrum and low-toxicity, 17 benzamides substituted with quinoline-linked 1,2,4-oxadiazole were designed using the splicing principle of active substructures and were synthesized. The biological activities were evaluated against… read more here.
Keywords: quinoline linked; linked oxadiazole; substituted quinoline; toxicity ... See more keywords