Iodine‐Mediated Sulfonylation of Quinoline N‐Oxides: a Mild and Metal‐Free One‐Pot Synthesis of 2‐Sulfonyl Quinolines
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DOI: 10.1002/ajoc.201700001
Abstract: A synthetic strategy for an iodine-mediated sulfonylation of quinoline N-oxides has been developed. A wide variety of 2-sulfonyl quinoline derivatives were synthesized by reacting various quinoline N-oxides with different sodium sulfinates in the presence of… read more here.
Keywords: quinoline oxides; mediated sulfonylation; iodine mediated; sulfonylation quinoline ... See more keywords
Regioselective Arylation of Quinoline N-Oxides (C8), Indolines (C7) and N-tert-Butylbenzamide with Arylboronic Acids
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DOI: 10.1021/acsomega.9b03884
Abstract: Herein, we disclose Ru(II)-catalyzed regioselective distal C(sp2)–H arylation of quinoline N-oxide with arylboronic acids to 8-arylquinolines. In the developed method, the Ru(II)-catalyst shows dual activity, that is, distal C–H activation of quinoline N-oxides followed by… read more here.
Keywords: indolines tert; quinoline oxides; quinoline; arylation quinoline ... See more keywords
Simple and scalable electrochemical synthesis of 2,1-benzisoxazoles and quinoline N-oxides.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc06054e
Abstract: Cathodic reduction of the nitro moiety and subsequent intramolecular cyclization affords different substituted 2,1-benzisoxazoles and quinoline N-oxides. This methodology allows the synthesis of two different types of heterocycles from common simple starting materials, using electrons… read more here.
Keywords: benzisoxazoles quinoline; quinoline oxides; simple scalable; synthesis benzisoxazoles ... See more keywords
The direct C–H alkenylation of quinoline N-oxides as a suitable strategy for the synthesis of promising antiparasitic drugs
Sign Up to like & getrecommendations! Published in 2020 at "New Journal of Chemistry"
DOI: 10.1039/c9nj05054j
Abstract: Functionalized quinolines are an important group of heterocyclic molecules with diverse, different, and interesting biological and pharmacological activities. Traditionally, several methods have been developed for the construction of this N-heterocyclic ring, but nowadays the functionalization… read more here.
Keywords: quinoline oxides; chemistry; direct alkenylation; alkenylation quinoline ... See more keywords
Zinc-catalyzed C-H alkenylation of quinoline N-oxides with ynones: a new strategy towards quinoline-enol scaffolds.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc00245g
Abstract: A zinc-catalyzed C-H alkenylation of quinoline N-oxides with ynones has been developed to rapidly assemble a broad collection of valuable quinoline-enol organic architectures. Uncommonly, this novel reaction involves C-H functionalization, and N-O, C-C and C[triple… read more here.
Keywords: quinoline oxides; quinoline; zinc catalyzed; catalyzed alkenylation ... See more keywords
Directed C8-H allylation of quinoline N-oxides with vinylcyclopropanes via sequential C-H/C-C activation.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d2cc06646g
Abstract: The Rh(III)-catalyzed C8-allylation of quinoline N-oxides has been accomplished using vinylcyclopropanes as an allyl source with excellent diastereoselectivity at room temperature. The C-H/C-C activation, substrate scope and natural product mutation are the important practical features. read more here.
Keywords: quinoline oxides; directed allylation; activation; allylation quinoline ... See more keywords
Copper-Catalyzed Deoxygenative C2-Sulfonylation of Quinoline N-Oxides with DABSO and Phenyldiazonium Tetrafluoroborates for the Synthesis of 2-Sulfonylquinolines via a Radical Reaction
Sign Up to like & getrecommendations! Published in 2019 at "Synthesis"
DOI: 10.1055/s-0037-1611787
Abstract: An efficient and practical method for the synthesis of 2-sulfonylquinolines through copper-catalyzed deoxygenative C2-sulfonylation of quinoline N-oxides with 1,4-diazabicyclo[2.2.2]octane bis(sulfur dioxide) (DABSO) and phenyldiazonium tetrafluoroborates is demonstrated. Products with various substituents were obtained in moderate… read more here.
Keywords: quinoline oxides; deoxygenative sulfonylation; sulfonylation quinoline; catalyzed deoxygenative ... See more keywords