Base-Promoted Synthesis of Quinoline-4(1H)-thiones from o-Alkynylanilines and Aroyl Isothiocyanates.
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DOI: 10.1021/acs.orglett.7b02993
Abstract: A base-promoted synthesis of quinoline-4(1H)-thiones has been accomplished from the in situ generated o-alkynylthiourea, obtained by reacting o-alkynylanilines with aroyl/acyl isothiocyanates. A 6-exo-dig S-cyclization of the in situ generated thiourea is followed by a rearrangement… read more here.
Keywords: promoted synthesis; synthesis quinoline; quinoline; alkynylanilines aroyl ... See more keywords