Lossen Rearrangement vs C-N Reductive Elimination Enabled by Rh(III)-Catalyzed C-H Activation/Selective Lactone Ring-Opening: Chemodivergent Synthesis of Quinolinones and Dihydroisoquinolinones.
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DOI: 10.1021/acs.orglett.0c03734
Abstract: An unprecedented Rh(III)-catalyzed cascade C-H activation/Lossen rearrangement of aromatic amides with methyleneoxetanones has been realized along with a tunable C-N bond reductive elimination/trans esterification, giving divergent access to quinolinones and dihydroisoquinolinones via selective ring-opening of… read more here.
Keywords: ring opening; lossen rearrangement; iii catalyzed; activation ... See more keywords