Design, Synthesis, in vitro and in silico Characterization of 2‐Quinolone‐L‐alaninate‐1,2,3‐triazoles as Antimicrobial Agents
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202100714
Abstract: Due to the ever‐increasing antimicrobial resistance there is an urgent need to continuously design and develop novel antimicrobial agents. Inspired by the broad antibacterial activities of various heterocyclic compounds such as 2‐quinolone derivatives, we designed… read more here.
Keywords: design synthesis; quinolone; quinolone alaninate; antimicrobial agents ... See more keywords
Update on Quinolone Allergy: A Complementary Note
Sign Up to like & getrecommendations! Published in 2017 at "Current Allergy and Asthma Reports"
DOI: 10.1007/s11882-017-0742-x
Abstract: Dear Editor-in-Chief, We read the recent update on quinolone allergy by Doña I et al. [1] with great interest. Although this review is elegantly written and contains valuable information for the reader of the Journal,… read more here.
Keywords: update quinolone; activation; mast cell; hypersensitivity ... See more keywords
Identification of quinolone derivatives as effective anti-Dengue virus agents.
Sign Up to like & getrecommendations! Published in 2020 at "Antiviral research"
DOI: 10.1016/j.antiviral.2020.104969
Abstract: Dengue virus (DENV) infection is one of the most important infectious diseases in tropical and subtropical regions around the world. Previously, we performed an initial phenotypic screening of 7,000 compounds using DENV type 2 (DENV2)-infected… read more here.
Keywords: dengue virus; virus; compound; quinolone ... See more keywords
Strategies of porous network quinolone polymers: A comprehensive evaluation of their biological activity
Sign Up to like & getrecommendations! Published in 2021 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2020.108809
Abstract: Abstract Hydrazine polymers were synthesized under the condition of hydrazine hydrate/ethanol by a clever one-pot method, and then treated with methanesulfonyl chloride and acetyl chloride, respectively, two new quinolones were easily obtained. The basic structure… read more here.
Keywords: quinolone; strategies porous; porous network; cell ... See more keywords
Understanding and Sensitizing Density-Dependent Persistence to Quinolone Antibiotics.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular cell"
DOI: 10.1016/j.molcel.2017.11.012
Abstract: Physiologic and environmental factors can modulate antibiotic activity and thus pose a significant challenge to antibiotic treatment. The quinolone class of antibiotics, which targets bacterial topoisomerases, fails to kill bacteria that have grown to high… read more here.
Keywords: persistence quinolone; density; quinolone antibiotics; persistence ... See more keywords
Four Specific Hapten Conformations Dominating Antibody Specificity: Quantitative Structure-Activity Relationship Analysis for Quinolone Immunoassay.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.7b00997
Abstract: Antibody-based immunoassay methods have been important tools for monitoring drug residues in animal foods. However, because of limited knowledge about the quantitative structure-activity relationships between a hapten and its resultant antibody specificity, antibody production with… read more here.
Keywords: quantitative structure; antibody; structure activity; antibody specificity ... See more keywords
Quinolone-3-amidoalkanol: A New Class of Potent and Broad-Spectrum Antimicrobial Agent
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.3c01406
Abstract: Herein, we describe 39 novel quinolone compounds bearing a hydrophilic amine chain and varied substituted benzyloxy units. These compounds demonstrate broad-spectrum activities against acid-fast bacterium, Gram-positive and -negative bacteria, fungi, and leishmania parasite. Compound 30… read more here.
Keywords: quinolone amidoalkanol; quinolone; new class; amidoalkanol new ... See more keywords
Enzymatic one-step ring contraction for quinolone biosynthesis
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DOI: 10.1038/s41467-018-05221-5
Abstract: The 6,6-quinolone scaffolds on which viridicatin-type fungal alkaloids are built are frequently found in metabolites that display useful biological activities. Here we report in vitro and computational analyses leading to the discovery of a hemocyanin-like… read more here.
Keywords: enzymatic one; biosynthesis; step; step ring ... See more keywords
Recent advances in the synthesis of pharmaceutically active 4-quinolone and its analogues: a review
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DOI: 10.1039/d3ra00749a
Abstract: 4-Quinolone and its analogs are heterocyclic classes of organic compounds displaying biologically active and a broad spectrum of pharmaceutical drug scaffolds. 4-Quinolone is the first-line chemotherapeutic treatment for a wide spectrum of bacterial infections. Recently,… read more here.
Keywords: synthesis pharmaceutically; active quinolone; quinolone; recent advances ... See more keywords
A foundational theoreticalAl12E12(E = N, P) adsorption and quinolone docking study: cage–quinolone pairs, optics and possible therapeutic and diagnostic applications
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2053742
Abstract: Abstract This combined Al12 E 12 (E = N, P) surface adsorption and docking study describes the new possibility of prospective potential probing(photophysical/optical) and therapy(medicinal/biochemical) with these adsorbent conjugates. DFT investigations were undertaken herein to help generate… read more here.
Keywords: adsorption; structure; see reference; quinolone ... See more keywords
Discovery of N-quinazolinone-4-hydroxy-2-quinolone-3-carboxamides as DNA gyrase B-targeted antibacterial agents
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2084088
Abstract: Abstract Emerging drug resistance is generating an urgent need for novel and effective antibiotics. A promising target that has not yet been addressed by approved antibiotics is the bacterial DNA gyrase subunit B (GyrB), and… read more here.
Keywords: hydroxy quinolone; targeted antibacterial; dna gyrase; quinolone carboxamides ... See more keywords