Recent advances in the synthetic and medicinal perspective of quinolones: A review.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103291
Abstract: In the modern scenario, the quinolone scaffold has emerged as a very potent motif considering its clinical significance. Quinolones possess wide range of pharmacological activities such as anticancer, antibacterial, antifungal, antiprotozoal, antiviral, anti-inflammatory, carbonic anhydrase… read more here.
Keywords: synthetic medicinal; biological activities; quinolone based; chemistry ... See more keywords
99mTc-Labeled Quinolone-Based Novel Skeletal Tracers for Tumor Visualization through Fibroblast Activation Protein.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c00132
Abstract: Fibroblast activation protein (FAP) has emerged as a prominent target for tumor diagnosis. Quinoline-based FAP PET tracers demonstrated clinical feasibility. However, there is a relative scarcity of clinical studies on 99mTc-labeled FAP SPECT tracers. The… read more here.
Keywords: quinolone based; 99mtc fapi; fibroblast activation; 99mtc labeled ... See more keywords
Synthesis and In vitro Biological Evaluation of Quinolone-Based Hydrazones as Potential Antidiabetic Agents Targeting Key Metabolic Enzymes
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DOI: 10.1021/acsomega.5c04663
Abstract: A series of novel structures featuring quinolone-based hydrazones (5a–5q) were synthesized, characterized, and screened for their potential inhibition of key enzymes involved in carbohydrate metabolism, namely human pancreatic α-amylase (HPA) and human lysosomal acid α-glucosidase,… read more here.
Keywords: quinolone based; antidiabetic agents; aldose reductase; based hydrazones ... See more keywords