Structural basis of quinolone derivatives, inhibition of type I and II topoisomerases and inquiry into the relevance of bioactivity in odd or even branches with molecular docking study
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DOI: 10.1016/j.molstruc.2020.128869
Abstract: Abstract The structural modification of quinolone derivatives has been a hot spot in recent years, especially the modification of the N-1 position, which is the part that this article focuses on. In this paper, series… read more here.
Keywords: structural basis; basis quinolone; odd even; quinolone derivatives ... See more keywords
Preliminary Studies of Antimicrobial Activity of New Synthesized Hybrids of 2-Thiohydantoin and 2-Quinolone Derivatives Activated with Blue Light
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DOI: 10.3390/molecules27031069
Abstract: Thiohydantoin and quinolone derivatives have attracted researchers’ attention because of a broad spectrum of their medical applications. The aim of our research was to synthesize and analyze the antimicrobial properties of novel 2-thiohydantoin and 2-quinolone… read more here.
Keywords: thiohydantoin quinolone; preliminary studies; blue light; quinolone ... See more keywords
In Vitro and In Silico Biological Studies of 4-Phenyl-2-quinolone (4-PQ) Derivatives as Anticancer Agents
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DOI: 10.3390/molecules28020555
Abstract: Our previous study found that 2-phenyl-4-quinolone (2-PQ) derivatives are antimitotic agents, and we adopted the drug design concept of scaffold hopping to replace the 2-aromatic ring of 2-PQs with a 4-aromatic ring, representing 4-phenyl-2-quinolones (4-PQs).… read more here.
Keywords: silico biological; vitro silico; quinolone derivatives; anticancer ... See more keywords