1,2,4-Triazole-quinoline/quinolone hybrids as potential anti-bacterial agents.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.04.033
Abstract: Bacterial infections, caused predominately by Gram-positive and Gram-negative organisms, are proliferation of harmful strains of bacteria on or inside the body. Hospital-acquired and community-acquired bacterial infections have already put a heavy burden on the global… read more here.
Keywords: anti bacterial; triazole quinoline; quinolone hybrids; quinoline quinolone ... See more keywords
Design and Synthesis of New Pyrimidine-Quinolone Hybrids as Novel hLDHA Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15070792
Abstract: A battery of novel pyrimidine-quinolone hybrids was designed by docking scaffold replacement as lactate dehydrogenase A (hLDHA) inhibitors. Structures with different linkers between the pyrimidine and quinolone scaffolds (10-21 and 24–31) were studied in silico,… read more here.
Keywords: hldha inhibitors; new pyrimidine; quinolone; quinolone hybrids ... See more keywords
Recent advances in quinolone hybrids with potential antibacterial activity against drug-resistant bacteria.
Sign Up to like & getrecommendations! Published in 2023 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2023-0002
Abstract: Quinolone derivatives, represented by fluoroquinolones, have emerged as the most commonly prescribed antibacterials for the treatment of various bacterial infections. In particular, the combination of a quinolone moiety with other antibacterial pharmacophores has the potential to act… read more here.
Keywords: quinolone hybrids; potential antibacterial; activity; drug resistant ... See more keywords