Understanding the Inhibitory and Antioxidant Effects of Pyrroloquinoline Quinone (PQQ) on Copper(II)-Induced α-Synuclein-119 Aggregation.
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DOI: 10.1021/acschemneuro.1c00703
Abstract: Parkinson's disease (PD) is associated with the aggregation and misfolding of a-synuclein (a-syn) protein in dopaminergic neurons. The misfolding process is heavily linked to copper dysregulation in PD. Experimental evidence supports the hypothesis that the… read more here.
Keywords: aggregation; quinone pqq; pyrroloquinoline quinone; syn 119 ... See more keywords