A New Method for the Synthesis of Substituted 8,9,10,11-Tetrahydroindolo[1,2-a]Quinoxalin-6(5H)-Ones
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DOI: 10.1007/s10593-017-2090-0
Abstract: The reaction of 1-(cyclohexen-1-yl)pyrrolidines with 3-(α-chlorobenzyl)quinoxalin-2(1H)-ones resulted in the formation of 8,9,10,11-tetrahydroindolo[1,2-a]quinoxalin-6(5H)-ones via a tandem sequence of Stork enamine alkylation and intramolecular annulation. Oxidative dehydrogenation gave indolo[1,2-a]quinoxalin-6(5H)-one. read more here.
Keywords: new method; synthesis substituted; quinoxalin ones; tetrahydroindolo quinoxalin ... See more keywords
Mn(OAc)3*2H2O promoted addition of arylboronic acids to quinoxalin-2-ones
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DOI: 10.1016/j.tetlet.2017.12.085
Abstract: Abstract A simple method has been developed for the synthesis of 3-aryl quinoxalin-2-one derivatives through an oxidative cross-coupling of arylboronic acids with quinoxalin-2-ones using a readily available oxidant Mn(III) acetate dihydrate. This method provides 3-aryl… read more here.
Keywords: 2h2o promoted; quinoxalin ones; arylboronic acids; acids quinoxalin ... See more keywords
Cobalt-Catalyzed Direct C-H Carbonylative Synthesis of Free (NH)-Indolo[1,2-a]quinoxalin-6(5H)-ones.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c03900
Abstract: A cobalt-catalyzed direct C-H carbonylative reaction of N-(2-(1H-indol-1-yl)phenyl)picolinamides for the synthesis of (NH)-indolo[1,2-a]quinoxalin-6(5H)-one skeletons has been developed. Using benzene-1,3,5-triyl triformate (TFBen) as the CO source and picolinamide as the traceless directing group, various free (NH)-indolo[1,2-a]quinoxalin-6(5H)-ones… read more here.
Keywords: indolo quinoxalin; free indolo; cobalt catalyzed; catalyzed direct ... See more keywords
Visible-Light-Initiated Difunctionalization of Quinoxalin-2(1H)-ones with Acyloxy Nitroso Compounds.
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DOI: 10.1021/acs.orglett.2c02703
Abstract: Herein, a photoinitiated radical relay reaction of quinoxalin-2(1H)-ones, with acyloxy nitroso compounds as a source of radicals, is described. Although the C-H functionalization of quinoxalin-2(1H)-ones has been investigated, its difunctionalization, the simultaneous construction of C-C… read more here.
Keywords: acyloxy nitroso; difunctionalization; ones acyloxy; quinoxalin ones ... See more keywords
Transition-metal free direct C–H functionalization of quinoxalin-2(1H)-ones with oxamic acids leading to 3-carbamoyl quinoxalin-2(1H)-ones
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DOI: 10.1039/c9qo01322a
Abstract: A practical transition-metal free decarboxylative coupling reaction of oxamic acids with quinoxalin-2(1H)-ones has been developed under mild conditions. This transformation provides an efficient approach for the preparation of 3-carbamoyl quinoxalin-2(1H)-ones, which are important subunits in… read more here.
Keywords: transition metal; chemistry; oxamic acids; quinoxalin ones ... See more keywords
Visible-light-promoted acridine red catalyzed aerobic oxidative decarboxylative acylation of α-oxo-carboxylic acids with quinoxalin-2(1H)-ones
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DOI: 10.1039/c9qo01334b
Abstract: A mild and facile visible-light-mediated strategy has been proposed for the synthesis of 3-acyl quinoxalin-2(1H)-ones through acridine red catalyzed aerobic oxidative decarboxylative acylation of α-oxo-carboxylic acids with quinoxalin-2(1H)-ones at room temperature in air. Various 3-acyl… read more here.
Keywords: red catalyzed; acridine red; visible light; quinoxalin ones ... See more keywords
Facile Entry to Pharmaceutically Important 3-Difluoromethyl-Quinoxalin-2-Ones Enabled by Visible-Light-Driven Difluoromethylation of Quinoxalin-2-Ones
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15121552
Abstract: CF2H moiety has a significant potential utility in drug design and discovery, and the incorporation of CF2H into biologically active molecules represents an important and efficient strategy for seeking lead compounds and drug candidates. On… read more here.
Keywords: difluoromethylation; facile entry; difluoromethyl quinoxalin; quinoxalin ones ... See more keywords