Facile synthesis of C6‐substituted benz[4,5]imidazo[1,2‐a]quinoxaline derivatives and their anticancer evaluation
Sign Up to like & getrecommendations! Published in 2021 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202000393
Abstract: Cancer remains a leading cause of death worldwide, resulting in continuous efforts to discover and develop highly efficacious anticancer drugs. High‐throughput screening of heterocyclic compound libraries is one of the promising approaches that provided several… read more here.
Keywords: quinoxaline derivatives; cell; cell line; cancer cell ... See more keywords
Design, synthesis, molecular docking and anti-proliferative evaluations of [1,2,4]triazolo[4,3-a]quinoxaline derivatives as DNA intercalators and Topoisomerase II inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104399
Abstract: In view of their DNA intercalation activities as anticancer agents, novel twenty four [1,2,4]triazolo[4,3-a]quinoxaline derivatives have been designed, synthesized and evaluated against HepG2, HCT-116 and MCF-7 as DNA intercalators and Top II enzyme inhibitors. The… read more here.
Keywords: dna; triazolo quinoxaline; dna intercalators; quinoxaline derivatives ... See more keywords
Alternating polymers based on alkoxy-phenyl substituted indacenodithiophene and fluorinated quinoxaline derivatives for photovoltaic cells
Sign Up to like & getrecommendations! Published in 2017 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2017.06.023
Abstract: Abstract To effectively modulate the molecular energy levels of indacenodithiophene (IDT)-based donor-acceptor (D-A) polymers, 4-hexyloxy-phenyl and 3-fluorine-4-hexyloxy-phenyl substituted IDT derivatives were designed and copolymerized with fluorinated quinoxaline derivatives (0F, 1F and 2F) to construct a… read more here.
Keywords: alternating polymers; energy; phenyl; phenyl substituted ... See more keywords
Achieving dual-responsive fluorescence switching towards mechanical force and volatile acid vapor based on D-A type diphenylamine functionalized quinoxaline derivatives
Sign Up to like & getrecommendations! Published in 2021 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2021.109763
Abstract: Abstract New D-A type diphenylamine modified quinoxaline derivatives DPA-DPQ and 2DPA-DPQ have been synthesized by the classical nucleophilic substitution reaction. Two compounds exhibit obvious solvatochromism in different polarities of the solvents. Spectral change and theoretical… read more here.
Keywords: fluorescence; type diphenylamine; achieving dual; force ... See more keywords
Design, synthesis, molecular modeling and anti-proliferative evaluation of novel quinoxaline derivatives as potential DNA intercalators and topoisomerase II inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.06.004
Abstract: New series of [1,2,4]triazolo [4,3-a]quinoxaline and bis([1,2,4]triazolo)[4,3-a:3',4'-c]quinoxaline derivatives have been designed, synthesized and biologically evaluated for their cytotoxic activities against three tumor cell lines (HePG-2, Hep-2 and Caco-2). Compounds 16e, 21, 25a and 25b exhibited… read more here.
Keywords: design synthesis; anti proliferative; dna; quinoxaline derivatives ... See more keywords
Identification of 3-(benzazol-2-yl)quinoxaline derivatives as potent anticancer compounds: Privileged structure-based design, synthesis, and bioactive evaluation in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.01.004
Abstract: Inspired by the common structural characteristics of numerous known antitumor compounds targeting DNA or topoisomerase I, 3-(benzazol-2-yl)-quinoxaline-based scaffold was designed via the combination of two important privileged structure units -quinoxaline and benzazole. Thirty novel 3-(benzazol-2-yl)-quinoxaline… read more here.
Keywords: benzazol quinoxaline; quinoxaline derivatives; chemistry; privileged structure ... See more keywords
Efficient alternating polymer based on benzodithiophene and di-fluorinated quinoxaline derivatives for bulk heterojunction photovoltaic cells
Sign Up to like & getrecommendations! Published in 2017 at "Polymer"
DOI: 10.1016/j.polymer.2017.03.056
Abstract: Abstract A new donor-acceptor polymer ( PBDTT-DFTQ ) based on two-dimensional conjugated alkylthienyl substituted benzo[1,2-b:4,5-b′]dithiophene and two fluorine substituted quinoxaline derivatives was synthesized and applied as donor materials for bulk heterojunction solar cells. Thermal stability,… read more here.
Keywords: alternating polymer; bulk heterojunction; polymer; quinoxaline derivatives ... See more keywords
Green Design, Synthesis, and Molecular Docking Study of Novel Quinoxaline Derivatives with Insecticidal Potential against Aphis craccivora
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c03332
Abstract: An efficient and environmentally friendly method was established for designing novel 3-amino-1,4-dihydroquinoxaline-2-carbonitrile (1) via the reaction of bromomalononitrile and benzene-1,2-diamine under microwave irradiation in an excellent yield (93%). This targeted amino derivative was utilized for… read more here.
Keywords: aphis craccivora; docking study; molecular docking; quinoxaline derivatives ... See more keywords
FeCl3-Catalyzed synthesis of pyrrolo[1,2-a]quinoxaline derivatives from 1-(2-aminophenyl)pyrroles through annulation and cleavage of cyclic ethers.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc07089f
Abstract: A straightforward Fe-catalyzed method for the synthesis of pyrrolo[1,2-a]quinoxalines from 1-(2-aminophenyl)pyrroles and cyclic ethers, which includes functionalization of C(sp3)-H bonds and the construction of C-C and C-N bonds, has been developed. The features of this… read more here.
Keywords: aminophenyl pyrroles; synthesis pyrrolo; pyrrolo; cyclic ethers ... See more keywords
Functionalization of gold nanoparticles with two aminoalcohol-based quinoxaline derivatives for targeting phosphoinositide 3-kinases (PI3Kα)
Sign Up to like & getrecommendations! Published in 2019 at "New Journal of Chemistry"
DOI: 10.1039/c8nj04314k
Abstract: Quinoxaline derivatives have attracted considerable attention due to their vast range of applications that includes electroluminescence and biomedicine. read more here.
Keywords: nanoparticles two; aminoalcohol based; gold nanoparticles; quinoxaline derivatives ... See more keywords
Synthesis of novel antibacterial and antifungal quinoxaline derivatives
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d1ra07559d
Abstract: A series of quinoxaline derivatives were designed, synthesized and evaluated as antimicrobial agents against plant pathogenic bacteria and fungi. Some of these compounds exhibited significant antibacterial and antifungal activities in vitro. Compound 5k displayed good… read more here.
Keywords: quinoxaline derivatives; novel antibacterial; antibacterial antifungal; antifungal quinoxaline ... See more keywords