A Comparative Study of Conventional and Microwave-Assisted Synthesis of Quinoxaline 1,4-di-N-oxide N-acylhydrazones Derivatives Designed as Antitubercular Drug Candidates
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DOI: 10.1002/jhet.2830
Abstract: Quinoxaline 1,4-di-N-oxide (QdNO) and N-acylhydrazone subunit are considered privileged scaffolds in medicinal chemistry because of its wide spectrum of biological activities, such as antibacterial, antitubercular, antiviral, anticancer, and antifungal. Beirut's reaction is the mostly commonly… read more here.
Keywords: quinoxaline oxide; chemistry; microwave assisted; assisted synthesis ... See more keywords
Cathepsin L Inhibitors with Activity against the Liver Fluke Identified From a Focus Library of Quinoxaline 1,4-di-N-Oxide Derivatives
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DOI: 10.3390/molecules24132348
Abstract: Infections caused by Fasciola species are widely distributed in cattle and sheep causing significant economic losses, and are emerging as human zoonosis with increasing reports of human cases, especially in children in endemic areas. The… read more here.
Keywords: quinoxaline oxide; activity liver; oxide derivatives; inhibitors activity ... See more keywords