Bis(het)aryl-1,2,3-triazole quinuclidines as α7 nicotinic acetylcholine receptor ligands: Synthesis, structure affinity relationships, agonism activity, [18F]-radiolabeling and PET study in rats.
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DOI: 10.1016/j.ejmech.2019.06.049
Abstract: In this paper we describe the design and synthesis of bis(Het)Aryl-1,2,3-triazole quinuclidine α7R ligands using an efficient three-step sequence including a Suzuki-Miyaura cross coupling reaction with commercially available and home-made boron derivatives. The exploration of… read more here.
Keywords: bis het; nicotinic acetylcholine; quinuclidines nicotinic; triazole quinuclidines ... See more keywords