Non-IDH1-R132H IDH1/2 mutations are associated with increased DNA methylation and improved survival in astrocytomas, compared to IDH1-R132H mutations
Sign Up to like & getrecommendations! Published in 2021 at "Acta Neuropathologica"
DOI: 10.1007/s00401-021-02291-6
Abstract: Somatic mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 occur at high frequency in several tumour types. Even though these mutations are confined to distinct hotspots, we show that gliomas are the only tumour… read more here.
Keywords: r132h; r132h idh1; idh1 r132h; dna methylation ... See more keywords
R132 mutations in canine isocitrate dehydrogenase 1 (IDH1) lead to functional changes
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DOI: 10.1007/s11259-017-9707-8
Abstract: Glioma is the second most common intracranial neoplasia in dogs, but the pathogenic mechanisms remain unclear. In humans, isocitrate dehydrogenase 1 (IDH1) is frequently mutated in gliomas. Although almost all human IDH1 mutations have been… read more here.
Keywords: r132h; isocitrate dehydrogenase; dehydrogenase idh1; r132s ... See more keywords
Visual and semiquantitative 11C-methionine PET: an independent prognostic factor for survival of newly diagnosed and treatment-naïve gliomas
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DOI: 10.1093/neuonc/nox177
Abstract: Background Few data exist regarding the prognostic value of L-[S-methyl-11C]methionine (MET) PET for treatment-naïve gliomas. Methods A total of 160 glioma patients (89 men, 71 women; mean age: 45, range 18-84 y) underwent a MET… read more here.
Keywords: gliomas; treatment; 11c methionine; r132h ... See more keywords
Loss of BCAT1 Expression is a Sensitive Marker for IDH-Mutant Diffuse Glioma.
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DOI: 10.1093/neuros/nyy338
Abstract: BACKGROUND IDH mutation is an important prognostic factor of diffuse astrocytomas. Although the majority of IDH mutations could be identified by immunohistochemical (IHC) stain for R132H-mutant IDH1, DNA sequencing would be required for IHC negative… read more here.
Keywords: diffuse; idh mutations; bcat1; r132h ... See more keywords
IDH1 Expression via the R132H Mutation–Specific Antibody in Adrenocortical Neoplasias—Prognostic Impact in Carcinomas
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvaa018
Abstract: Abstract Context Mutations to isocitrate dehydrogenase (IDH) appear to play a prognostic or predictive role in several neoplasias. Immunohistochemical staining designed to detect a specific R132H mutation to IDH1 showed expression in the normal adrenal… read more here.
Keywords: carcinomas; staining; adrenocortical tumors; r132h mutation ... See more keywords
Characterization of an IDH1 R132H Rabbit Monoclonal Antibody, MRQ-67, and Its Applications in the Identification of Diffuse Gliomas
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DOI: 10.3390/antib12010014
Abstract: The current diagnosis of diffuse glioma involves isocitrate dehydrogenase (IDH) mutation testing. Most IDH mutant gliomas carry a G-to-A mutation at IDH1 position 395, resulting in the R132H mutant. R132H immunohistochemistry (IHC), therefore, is used… read more here.
Keywords: r132h mutant; idh1 r132h; mutation; mrq ... See more keywords