Aberrant PLN-R14del Protein Interactions Intensify SERCA2a Inhibition, Driving Impaired Ca2+ Handling and Arrhythmogenesis
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DOI: 10.3390/ijms23136947
Abstract: Phospholamban (PLN), a key modulator of Ca2+-homeostasis, inhibits sarcoplasmic reticulum (SR) calcium-ATPase (SERCA2a) and regulates cardiac contractility. The human PLN mutation R14del has been identified in arrhythmogenic cardiomyopathy patients worldwide and is currently extensively investigated.… read more here.
Keywords: inhibition; serca2a; r14del; pln r14del ... See more keywords
Myofilament Alterations Associated with Human R14del-Phospholamban Cardiomyopathy
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DOI: 10.3390/ijms24032675
Abstract: Phospholamban (PLN) is a major regulator of cardiac contractility, and human mutations in this gene give rise to inherited cardiomyopathies. The deletion of Arginine 14 is the most-prevalent cardiomyopathy-related mutation, and it has been linked… read more here.
Keywords: r14del pln; phospholamban; r14del; myofilament alterations ... See more keywords