Generation of R272Q, S156A and K572R RHOT1/Miro1 point mutations in iPSCs from a healthy individual using FACS-assisted CRISPR/Cas9 genome editing.
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DOI: 10.1016/j.scr.2021.102469
Abstract: The GTPase Miro1 is tail anchored into the mitochondrial outer membrane and tethers mitochondria to molecular motors which is crucial for mitochondrial transport. Miro1 contains two EF hand, ion binding domains important for calcium sequestration.… read more here.
Keywords: k572r; point mutations; r272q s156a; generation r272q ... See more keywords