A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self-ligands
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DOI: 10.1126/scisignal.abc4479
Abstract: Weakening autoinhibition of the kinase ZAP70 leads to overactive T cells and autoimmune disease. Stronger responses to weak ligands The protein tyrosine kinase ZAP70 links activated T cell antigen receptors (TCRs) to downstream signaling pathways.… read more here.
Keywords: responses weak; r360p mutation; zap70; cell ... See more keywords