Hypertrophic cardiomyopathy mutation R58Q in the myosin regulatory light chain perturbs thick filament-based regulation in cardiac muscle
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DOI: 10.1016/j.yjmcc.2018.02.009
Abstract: Hypertrophic cardiomyopathy (HCM) is frequently linked to mutations in the protein components of the myosin-containing thick filaments leading to contractile dysfunction and ultimately heart failure. However, the molecular structure-function relationships that underlie these pathological effects… read more here.
Keywords: mutation; myosin; hypertrophic cardiomyopathy; thick filament ... See more keywords