The choice of linker for conjugating R848 to inactivated influenza virus determines the stimulatory capacity for innate immune cells.
Sign Up to like & getrecommendations! Published in 2018 at "Vaccine"
DOI: 10.1016/j.vaccine.2018.01.035
Abstract: Inactivated influenza vaccines are not approved for use in infants less than 6 months of age due to poor immunogenicity in that population. While the live attenuated influenza vaccine has the potential to be more immunogenic,… read more here.
Keywords: immune; inactivated influenza; choice linker; vaccine ... See more keywords
A sugar modified amphiphilic cationic nano-adjuvant ceased tumor immune suppression and rejuvenated peptide vaccine induced antitumor immunity in cervical cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Biomaterials science"
DOI: 10.1039/d2bm01715f
Abstract: Human papilloma virus (HPV), one of the most common cancer-causing viruses, accounts for more than 90% of human anal and cervical cancers. Clinical studies have focused on adjuvant therapy with vaccines to improve therapeutic outcomes… read more here.
Keywords: cancer; r848; hpv; nano adjuvant ... See more keywords
Toward a More Precise Solution to Asthma Therapy
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2021-0227ed
Abstract: Asthma is a common and complex disease, clinically defined by compatible symptomatology (wheezing and dyspnea) and reversible airflow obstruction with long-term sequelae of airway remodeling and hyperresponsiveness (1, 2). The pathogenesis of asthma is a… read more here.
Keywords: r848; phenotype; asthma; th2 ... See more keywords
R848 Adjuvant Laden With Self-Assembled Nanoparticle-Based mRNA Vaccine Elicits Protective Immunity Against H5N1 in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.836274
Abstract: In order to perfect the design strategy of messenger RNA (mRNA) vaccines against the H5N1 influenza virus, we investigated whether different antigen designs and the use of adjuvants could improve the immune effect of mRNA… read more here.
Keywords: r848; cd5 flu; lnp man; man ... See more keywords
Cationic lipid-assisted nanoparticles for simultaneous delivery of CD47 siRNA and R848 to promote antitumor immune responses
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1142374
Abstract: Introduction: Triple-negative breast cancer (TNBC) usually has a poor prognosis. Although the immunotherapy of TNBC has achieved great progress, only a few patients can benefit from the current treatment. CD47 is widely expressed on the… read more here.
Keywords: r848; cd47; cd47 sirna; tnbc ... See more keywords
Systemic Administration of the TLR7/8 Agonist Resiquimod (R848) to Mice Is Associated with Transient, In Vivo-Detectable Brain Swelling
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11020274
Abstract: Simple Summary Physiological changes to the body can affect the brain. For example, inflammation that originates in the body can be sensed by the brain. In this study, we used an agent called resiquimod (R848)… read more here.
Keywords: mice; brain swelling; administration; resiquimod r848 ... See more keywords