Structure-function analyses of candidate small molecule RPN13 inhibitors with antitumor properties
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DOI: 10.1371/journal.pone.0227727
Abstract: We sought to design ubiquitin-proteasome system inhibitors active against solid cancers by targeting ubiquitin receptor RPN13 within the proteasome’s 19S regulatory particle. The prototypic bis-benzylidine piperidone-based inhibitor RA190 is a michael acceptor that adducts Cysteine… read more here.
Keywords: cell lines; ra375; piperidone; function ... See more keywords