Preclinical study of rAAV2-sTRAIL: pharmaceutical efficacy, biodistribution and safety in animals
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DOI: 10.1038/cgt.2017.12
Abstract: The recombinant sTRAIL has been in clinical trial for various human malignancies. However, the half-life time of sTRAIL is very short, which might be an important factor influencing its clinical efficacy for cancer therapy. We… read more here.
Keywords: safety; efficacy; raav2 strail95; strail95 281 ... See more keywords
In utero delivery of rAAV2/9 induces neuronal expression of the transgene in the brain: towards new models of Parkinson’s disease
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DOI: 10.1038/gt.2017.84
Abstract: Animal models are essential tools for basic pathophysiological research as well as validation of therapeutic strategies for curing human diseases. However, technical difficulties associated with classical transgenesis approaches in rodent species higher than Mus musculus… read more here.
Keywords: delivery; expression; utero delivery; transgene ... See more keywords