The VPS34 PI3K negatively regulates RAB-5 during endosome maturation
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DOI: 10.1242/jcs.194746
Abstract: ABSTRACT The GTPase Rab5 and phosphatidylinositol-3 phosphate [PI(3)P] coordinately regulate endosome trafficking. Rab5 recruits Vps34, the class III phosphoinositide 3-kinase (PI3K), to generate PI(3)P and recruit PI(3)P-binding proteins. Loss of Rab5 and loss of Vps34… read more here.
Keywords: rab5; pi3k; vps34; rab endosome ... See more keywords