Dual Arginine Recognition of LRRK2 phosphorylated Rab GTPases.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2021.03.030
Abstract: Parkinson's disease-associated LRRK2 is a multi-domain Ser/Thr kinase that phosphorylates a subset of Rab GTPases to control their effector functions. Rab GTPases are the prime regulators of membrane trafficking in eukaryotic cells. Rabs exert their… read more here.
Keywords: rab; rab gtpases; dual arginine; lrrk2 phosphorylated ... See more keywords
Role of Rab GTPases in Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00387
Abstract: Alzheimer's disease (AD) comprises two major pathological hallmarks: extraneuronal deposition of β-amyloid (Aβ) peptides ("senile plaques") and intraneuronal aggregation of the microtubule-associated protein tau ("neurofibrillary tangles"). Aβ is derived from sequential cleavage of the β-amyloid… read more here.
Keywords: alzheimer disease; rab; rab gtpases; role rab ... See more keywords
Lipid rafts, Rab GTPases, and a late endosomal checkpoint for plasma membrane recycling
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2302320120
Abstract: The concept of compact, ordered sphingolipid–cholesterol membrane domains that function as “rafts” with biologically relevant functions was first put forward 26 y ago (1). Since then, the field of “lipid rafts” has blossomed and matured… read more here.
Keywords: rab gtpases; lipid rafts; raft; membrane domains ... See more keywords
Rabifier2: an improved bioinformatic classifier of Rab GTPases
Sign Up to like & getrecommendations! Published in 2017 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btw654
Abstract: Summary: The Rab family of small GTPases regulates and provides specificity to the endomembrane trafficking system; each Rab subfamily is associated with specific pathways. Thus, characterization of Rab repertoires provides functional information about organisms and… read more here.
Keywords: improved bioinformatic; rab; rab gtpases; rabifier2 improved ... See more keywords
RAB GTPases in the Basal Land Plant Marchantia polymorpha
Sign Up to like & getrecommendations! Published in 2018 at "Plant and Cell Physiology"
DOI: 10.1093/pcp/pcy027
Abstract: The RAB GTPase is an evolutionarily conserved machinery component of membrane trafficking, which is the fundamental system for cell viability and higher order biological functions. The composition of RAB GTPases in each organism is closely… read more here.
Keywords: rab; membrane trafficking; rab gtpases; plant ... See more keywords
Rab GTPases, tethers, and SNAREs work together to regulate Arabidopsis cell plate formation
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2023.1120841
Abstract: Cell plates are transient structures formed by the fusion of vesicles at the center of the dividing plane; furthermore, these are precursors to new cell walls and are essential for cytokinesis. Cell plate formation requires… read more here.
Keywords: cell plate; cell; rab gtpases; plate formation ... See more keywords
Rab GTPases: Emerging Oncogenes and Tumor Suppressive Regulators for the Editing of Survival Pathways in Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12020259
Abstract: The Rab GTPase family of proteins are mediators of membrane trafficking, conferring identity to the cell membranes. Recently, Rab and Rab-associated factors have been recognized as major regulators of the intracellular positioning and activity of… read more here.
Keywords: rab; gtpases emerging; rab gtpases; tumor suppressive ... See more keywords