Interaction between optineurin and Rab1a regulates autophagosome formation in neuroblastoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24143
Abstract: Optineurin (OPTN) is an autophagy receptor protein that has been implicated in glaucoma and amyotrophic lateral sclerosis. OPTN‐mediated autophagy is a complex process involving many autophagy‐regulating proteins. Autophagy plays a critical role in removing damaged… read more here.
Keywords: rab1a; autophagosome formation; formation neuroblastoma; interaction ... See more keywords
MiR-1202 Exerts Neuroprotective Effects on OGD/R Induced Inflammation in HM Cell by Negatively Regulating Rab1a Involved in TLR4/NF-κB Signaling Pathway
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DOI: 10.1007/s11064-020-02991-7
Abstract: Recent studies have shown that the level of miR-1202 in peripheral blood is closely related to brain activity and cognitive function in patients with depression, and it is involved in glioma pathological progress. However, the… read more here.
Keywords: ogd induced; mir; inflammation; mir 1202 ... See more keywords
Aberrant expression of Rab1A and its prognostic significance in human colorectal cancer.
Sign Up to like & getrecommendations! Published in 2018 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201807_15505
Abstract: OBJECTIVE Colorectal cancer (CRC) is one of the most common types of cancer worldwide. Emerging evidence has verified that Rab1A plays an oncogenic role in several human malignancies including breast cancer, lung cancer, and hepatocellular… read more here.
Keywords: crc patients; expression; cancer; rab1a ... See more keywords
Dual function of Rab1A in secretion and autophagy: hypervariable domain dependence
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DOI: 10.26508/lsa.202201810
Abstract: Gyurkovska et al show that whereas both Rab1A and Rab1B regulate secretion, Rab1A-HVD enables it to localize to autophagosomes and regulate autophagy. This provides a mechanism for a dual functionality of a single Rab in… read more here.
Keywords: secretion autophagy; rab1a; hypervariable domain; secretion ... See more keywords
Targeted disruption of Rab1a causes early embryonic lethality
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DOI: 10.3892/ijmm.2022.5101
Abstract: Guanosine nucleotide diphosphate (GDP) dissociation inhibitor 2 (GDI2) regulates the GDP/guanosine triphosphate (GTP) exchange reaction of Rab proteins by inhibiting the dissociation of GDP and the subsequent binding of GTP. The present study aimed to… read more here.
Keywords: rab1a; embryonic lethality; disruption rab1a; gene ... See more keywords