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   Articles with "rab21" as a keyword



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Rab21, a Novel PS1 Interactor, Regulates γ-Secretase Activity via PS1 Subcellular Distribution

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recommendations! Published in 2017 at "Molecular Neurobiology"

DOI: 10.1007/s12035-017-0606-3

Abstract: Abstractγ-Secretase has been a therapeutical target for its key role in cleaving APP to generate β-amyloid (Aβ), the primary constituents of senile plaques and a hallmark of Alzheimer’s disease (AD) pathology. Recently, γ-secretase-associating proteins showed… read more here.

Keywords: ps1; secretase associating; secretase activity; rab21 ... See more keywords
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Structural insights into Rab21 GTPase activation mechanism by molecular dynamics simulations

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recommendations! Published in 2018 at "Molecular Simulation"

DOI: 10.1080/08927022.2017.1357813

Abstract: Abstract Rab proteins belong to the family of monomeric GTPases which are involved in the cellular membrane trafficking. Rab21 protein exists in interchangeable GTP- and GDP-bound states. Rabs switch between two active and inactive conformations… read more here.

Keywords: molecular dynamics; gtp; rab21; form ... See more keywords
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RAB21 controls autophagy and cellular energy homeostasis by regulating retromer-mediated recycling of SLC2A1/GLUT1

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recommendations! Published in 2022 at "Autophagy"

DOI: 10.1080/15548627.2022.2114271

Abstract: ABSTRACT The endosomal system maintains cellular homeostasis by coordinating multiple vesicular trafficking events, and the retromer complex plays a critical role in endosomal cargo recognition and sorting. Here, we demonstrate an essential role for the… read more here.

Keywords: retromer; rab21; rab21 depletion; energy ... See more keywords
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Rab21 regulates caveolin‐1‐mediated endocytic trafficking to promote immature neurite pruning

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recommendations! Published in 2023 at "EMBO Reports"

DOI: 10.15252/embr.202254701

Abstract: Transmembrane proteins are internalized by clathrin‐ and caveolin‐dependent endocytosis. Both pathways converge on early endosomes and are thought to share the small GTPase Rab5 as common regulator. In contrast to this notion, we show here… read more here.

Keywords: rab21; mediated endocytic; caveolin mediated; early endosomes ... See more keywords