Targeting the Lysosomal Degradation of Rab22a‐NeoF1 Fusion Protein for Osteosarcoma Lung Metastasis
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DOI: 10.1002/advs.202205483
Abstract: Rab22a‐NeoF fusion protein has recently been reported as a promising target for osteosarcoma lung metastasis. However, how this fusion protein is regulated in cells remains unknown. Here, using multiple screenings, it is reported that Rab22a‐NeoF1… read more here.
Keywords: rab22a neof1; osteosarcoma lung; fusion protein; rab22a ... See more keywords
Chromosomal translocation-derived aberrant Rab22a drives metastasis of osteosarcoma
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DOI: 10.1038/s41556-020-0522-z
Abstract: Osteosarcoma is a type of aggressive malignant bone tumour that frequently metastasizes to lungs, resulting in poor prognosis. However, the molecular mechanisms of lung metastasis of osteosarcoma remain poorly understood. Here we identify exon–intron fusion… read more here.
Keywords: rab22a; metastasis osteosarcoma; smggds 607; lung metastasis ... See more keywords
Rab22a Promotes Epithelial-Mesenchymal Transition in Papillary Thyroid Carcinoma by Activating PI3K/AKT/mTOR Signaling Pathway
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DOI: 10.1155/2022/1874550
Abstract: Background Rab22a is a member of the RAS superfamily, involved in early endosome formation and intracellular vesicle transport. Rab22a is significantly upregulated in a variety of malignant tumors. However, its function in thyroid cancer has… read more here.
Keywords: pi3k akt; thyroid; mtor signaling; akt mtor ... See more keywords
Vps9d1 regulates tubular endosome formation through specific activation of Rab22A.
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DOI: 10.1242/jcs.260522
Abstract: The small GTPase Rab22A is an important regulator of the formation of tubular endosomes, which are one of the types of recycling endosome compartments of the clathrin-independent endocytosis pathway. In order to regulate tubular endosome… read more here.
Keywords: endosome formation; vps9d1; rab22a; tubular endosome ... See more keywords
Circular RNA circ_0029589 promotes ox-LDL-induced endothelial cell injury through regulating RAB22A by serving as a sponge of miR-1197.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical hemorheology and microcirculation"
DOI: 10.3233/ch-221657
Abstract: BACKGROUND Dysfunction of endothelial cells is now considered a vital contributor to the pathogenesis of atherosclerosis (AS). Moreover, circular RNA (circRNA) circ_0029589 has been found to be involved in the regulation of oxidized low-density lipoprotein… read more here.
Keywords: circ 0029589; cell; endothelial cell; mir 1197 ... See more keywords