Rab25-Mediated EGFR Recycling Causes Tumor Acquired Radioresistance
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DOI: 10.1016/j.isci.2020.100997
Abstract: Summary Tumor acquired radioresistance remains as the major limit in cancer radiotherapy (RT). Rab25, a receptor recycling protein, has been reported to be enhanced in tumors with aggressive phenotype and chemotherapy resistance. In this study,… read more here.
Keywords: acquired radioresistance; egfr recycling; rab25; tumor acquired ... See more keywords
Rab25 promotes erlotinib resistance by activating the β1 integrin/AKT/β‐catenin pathway in NSCLC
Sign Up to like & getrecommendations! Published in 2019 at "Cell Proliferation"
DOI: 10.1111/cpr.12592
Abstract: Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR‐TKI) has significant therapeutic efficacy in non‐small‐cell lung cancer (NSCLC) patients. However, acquired resistance is inevitable and limits the long‐term efficacy of EGFR‐TKI. Our study aimed to investigate… read more here.
Keywords: egfr tki; promotes erlotinib; erlotinib resistance; resistance ... See more keywords
Abstract 2591: Role of Rab25 in Melanoma and its potential targeting
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2591
Abstract: Background: RAB25 is a protein that belongs to the RAB11 subfamily located in the lq22 locus of chromosome and is ubiquitously expressed in cells of the gastrointestinal mucosa, ileum, and kidney. Its role in tumorigenesis… read more here.
Keywords: rab25; role; expression; rab25 melanoma ... See more keywords
Epidermal growth factor-mediated Rab25 pathway regulates integrin β1 trafficking in colon cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Cell International"
DOI: 10.1186/s12935-018-0526-y
Abstract: BackgroundIntegrins play a critical role in carcinogenesis. Integrin β1 localization is regulated by the guanosine-5′-triphosphate hydrolase Rab25 and integrin β1 levels are elevated in the serum of colon cancer patients; thus, the present study examined… read more here.
Keywords: integrin; colon cancer; cancer; epidermal growth ... See more keywords
Rab25 GTPase: Functional roles in cancer
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DOI: 10.18632/oncotarget.19571
Abstract: Rab25, a small GTPase belongs to the Rab protein family, has a pivotal role in cancer pathophysiology. Rab25 governs cell-surface receptors recycling and cellular signaling pathways activation, allowing it to control a diverse range of… read more here.
Keywords: gtpase functional; rab25 gtpase; functional roles; roles cancer ... See more keywords
Rab25 acts as an oncogene and participates in the regulation of aerobic glycolysis via PKM2 in gastric adenocarcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Translational Cancer Research"
DOI: 10.21037/tcr-20-2597
Abstract: Background Rab25, a hub node of protein-protein interaction networks, has become one of the most popular tumor-associated proteins. Pyruvate kinase (PK) is the main rate-limiting enzyme in the glycolysis pathway and plays a significant role… read more here.
Keywords: pkm2; rab25; aerobic glycolysis; regulation aerobic ... See more keywords
Long non-coding RNA LINC00173 serves as sponge for miR-338-3p to promote prostate cancer progression via regulating Rab25.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202009_23011
Abstract: OBJECTIVE Long non-coding RNA LINC00173 (LINC00173) has been shown to facilitate the progression of a number of malignancies. In this study, we aimed to investigate the function of LINC00173 on prostate cancer (PCa) and discover… read more here.
Keywords: linc00173; rna; pca; mir 338 ... See more keywords