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   Articles with "rab32" as a keyword



Rab32 facilitates Schwann cell pyroptosis in rats following peripheral nerve injury by elevating ROS levels

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recommendations! Published in 2024 at "Journal of Translational Medicine"

DOI: 10.1186/s12967-024-04999-x

Abstract: Peripheral nerve injury (PNI) is commonly observed in clinical practice, yet the underlying mechanisms remain unclear. This study investigated the correlation between the expression of a Ras-related protein Rab32 and pyroptosis in rats following PNI,… read more here.

Keywords: cell pyroptosis; rab32; pyroptosis; schwann cell ... See more keywords

Rab32 uses its effector reticulon 3L to trigger autophagic degradation of mitochondria-associated membrane (MAM) proteins

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recommendations! Published in 2021 at "Biology Direct"

DOI: 10.1186/s13062-021-00311-9

Abstract: Background Rab32 is a small GTPase associated with multiple organelles but is particularly enriched at the endoplasmic reticulum (ER). Here, it controls targeting to mitochondria-ER contacts (MERCs), thus influencing composition of the mitochondria-associated membrane (MAM).… read more here.

Keywords: degradation; rab32; mitochondria associated; associated membrane ... See more keywords

The small GTPase Rab32 resides on lysosomes to regulate mTORC1 signaling.

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recommendations! Published in 2020 at "Journal of cell science"

DOI: 10.1242/jcs.236661

Abstract: Epithelial cells such as liver-resident hepatocytes rely heavily on the Rab family of small GTPases to perform membrane trafficking events that dictate cell physiology and metabolism. Not surprisingly, disruption of several Rabs can manifest in… read more here.

Keywords: mtorc1 signaling; rab32; resides lysosomes; gtpase rab32 ... See more keywords

MicroRNA-141-5p Acts as a Tumor Suppressor via Targeting RAB32 in Chronic Myeloid Leukemia

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recommendations! Published in 2019 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2019.01545

Abstract: MicroRNA-141-5p (miR-141-5p), an important member of the miR-200 family, has been reported to be involved in cellular proliferation, migration, invasion, and drug resistance in different kinds of human malignant tumors. However, the role and function… read more here.

Keywords: proliferation migration; microrna 141; rab32; mir 141 ... See more keywords