Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-16696-6
Abstract: Inherited peripheral neuropathies (IPNs) represent a broad group of disorders including Charcot-Marie-Tooth (CMT) neuropathies characterized by defects primarily arising in myelin, axons, or both. The molecular mechanisms by which mutations in nearly 100 identified IPN/CMT… read more here.
Keywords: lipid turnover; rab35; mtorc1; growth ... See more keywords
Stratum is required for both apical and basolateral transport through stable expression of Rab10 and Rab35 in Drosophila photoreceptors
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e21-12-0596
Abstract: Post-Golgi transport for specific membrane domains, also termed polarized transport, is essential for the construction and maintenance of polarized cells. Highly polarized Drosophila photoreceptors serve as a good model system for studying the mechanisms underlying… read more here.
Keywords: rab10 rab35; drosophila photoreceptors; stable expression; transport ... See more keywords
Rab35 regulates insulin secretion via phogrin in pancreatic β cells
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13581
Abstract: Dysfunction of pancreatic β cell insulin secretion is related to the pathogenesis of type 2 diabetes (T2D). Rab proteins have been shown to be key players in insulin secretion by pancreatic β cells, and phogrin… read more here.
Keywords: pancreatic cells; secretion; phogrin expression; insulin secretion ... See more keywords