RAB37 Hypermethylation Regulates Metastasis and Resistance to Docetaxel-Based Induction Chemotherapy in Nasopharyngeal Carcinoma
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DOI: 10.1158/1078-0432.ccr-18-0532
Abstract: Purpose: Epigenetic alterations play important roles in metastasis and drug resistance through gene regulation. However, the functional features and molecular mechanisms of epigenetic changes remain largely unclear in nasopharyngeal carcinoma (NPC) metastasis. Experimental Design: Gene… read more here.
Keywords: rab37; metastasis; nasopharyngeal carcinoma; rab37 hypermethylation ... See more keywords
Abstract 5875: Rab37 mediates intracellular trafficking and membrane presentation of PD-1 in T cells to foster an immunosuppressive microenvironment in lung cancer
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DOI: 10.1158/1538-7445.am2023-5875
Abstract: Programmed cell death protein 1 (PD-1) expressed on the surface of CD8+ T cells is known as an immune checkpoint protein. High expression of PD-1 leads to T-cell dysfunction in the tumor microenvironment (TME). Our… read more here.
Keywords: rab37; membrane presentation; intracellular trafficking; membrane ... See more keywords