Regulation of lipid homeostasis by the TBC protein dTBC1D22 via modulation of the small GTPase Rab40 to facilitate lipophagy.
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DOI: 10.1016/j.celrep.2021.109541
Abstract: The regulation of lipid homeostasis is not well understood. Using forward genetic screening, we demonstrate that the loss of dTBC1D22, an essential gene that encodes a Tre2-Bub2-Cdc16 (TBC) domain-containing protein, results in lipid droplet accumulation… read more here.
Keywords: lipophagy; regulation lipid; rab40; lipid homeostasis ... See more keywords