Regulation of Rab5 isoforms by transcriptional and post‐transcriptional mechanisms in yeast
Sign Up to like & getrecommendations! Published in 2017 at "Febs Letters"
DOI: 10.1002/1873-3468.12785
Abstract: Rab5 GTPases are master regulators of early endosome biogenesis and transport. The genome of Saccharomyces cerevisiae encodes three Rab5 proteins: Vps21, the major isoform, Ypt52 and Ypt53. Here, we show that Vps21 is the most… read more here.
Keywords: rab5; transcriptional mechanisms; post transcriptional; ypt53 ... See more keywords
The endocytic pathway taken by cationic substances requires Rab14 but not Rab5 and Rab7.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109945
Abstract: Endocytosis and endosome dynamics are controlled by proteins of the small GTPase Rab family. Besides possible recycling routes to the plasma membrane and various organelles, previously described endocytic pathways (e.g., clathrin-mediated endocytosis, macropinocytosis, CLIC/GEEC pathway)… read more here.
Keywords: rab5; endocytic pathway; requires rab14; pathway taken ... See more keywords
Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes
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DOI: 10.1038/s41467-021-21695-2
Abstract: The lipid phosphatidylinositol-3-phosphate (PI3P) is a regulator of two fundamental but distinct cellular processes, endocytosis and autophagy, so its generation needs to be under precise temporal and spatial control. PI3P is generated by two complexes… read more here.
Keywords: rab5; kinase; vps34; activation ... See more keywords
Identification of the Binding Sites on Rab5 and p110beta Phosphatidylinositol 3-kinase
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DOI: 10.1038/s41598-017-16029-6
Abstract: Rab5 is a small monomeric GTPase that mediates protein trafficking during endocytosis. Inactivation of Rab5 by GTP hydrolysis causes a conformational change that masks binding sites on its “switch regions” from downstream effectors. The p85… read more here.
Keywords: rab5; p110; rab5 gtp; phosphatidylinositol kinase ... See more keywords
c-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling
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DOI: 10.1038/s41598-019-42420-6
Abstract: During the development of the sympathetic nervous system, signals from tropomyosin-related kinase receptors (Trks) and p75 neurotrophin receptors (p75) compete to regulate survival and connectivity. During this process, nerve growth factor (NGF)- TrkA signaling in… read more here.
Keywords: rab5; death; neuronal death; p75 signaling ... See more keywords
The VPS34 PI3K negatively regulates RAB-5 during endosome maturation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.194746
Abstract: ABSTRACT The GTPase Rab5 and phosphatidylinositol-3 phosphate [PI(3)P] coordinately regulate endosome trafficking. Rab5 recruits Vps34, the class III phosphoinositide 3-kinase (PI3K), to generate PI(3)P and recruit PI(3)P-binding proteins. Loss of Rab5 and loss of Vps34… read more here.
Keywords: rab5; pi3k; vps34; rab endosome ... See more keywords
The exocyst complex and Rab5 are required for abscission by localizing ESCRT III subunits to the cytokinetic bridge
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Science"
DOI: 10.1242/jcs.226001
Abstract: ABSTRACT Cytokinesis is the final step of cell division following chromosome segregation that generates two daughter cells. The conserved exocyst complex is required for scission of the intercellular cytokinetic bridge, although the molecular mechanisms it… read more here.
Keywords: escrt iii; rab5; cytokinetic bridge; exocyst complex ... See more keywords
His Domain Protein Tyrosine Phosphatase and Rabaptin-5 couple endo-lysosomal sorting of EGFR with endosomal maturation.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cell science"
DOI: 10.1242/jcs.259192
Abstract: His Domain Protein Tyrosine Phosphatase (HD-PTP) collaborates with Endosomal Sorting Complexes Required for Transport (ESCRTs) to sort endosomal cargo into intralumenal vesicles, forming the multivesicular body. Completion of multivesicular body sorting is accompanied by maturation… read more here.
Keywords: rab5; domain protein; rabaptin; endosomal maturation ... See more keywords
The yeast LYST homolog Bph1 is a Rab5 effector and prevents Atg8 lipidation at endosomes.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cell science"
DOI: 10.1242/jcs.259421
Abstract: Lysosomes mediate degradation of macromolecules to their precursors for their cellular recycling. Additionally, lysosome-related organelles mediate cell type-specific functions. The Chédiak-Higashi syndrome is an autosomal, recessive disease, in which loss of the protein LYST causes… read more here.
Keywords: rab5; bph1; lyst homolog; homolog bph1 ... See more keywords
Impaired adipocyte glucose transport regulators in morbid obesity - Possible mechanisms contributing to metabolic dysfunction.
Sign Up to like & getrecommendations! Published in 2022 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202203_28361
Abstract: OBJECTIVE Obesity is characterized by hypertrophy and pathological expansion of adipocytes with impaired insulin signaling causing insulin resistance (IR) and metabolic dysfunction. We recently reported decreased expression of glucose transporter-4 (GLUT4) in cultured adipocytes from… read more here.
Keywords: rab5; glucose transport; gapex5; morbid obesity ... See more keywords